{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:18:59Z","timestamp":1786681139808,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T00:00:00Z","timestamp":1425254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic refractory vasomotor rhinitis (VMR) is a debilitating condition that causes significant impairment of quality of life. The purpose of this study is to investigate the efficacy and potential side effects of endoscopic vidian neurectomy as treatment for patients with VMR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a prospective, intent\u2010to\u2010follow case series. Inclusion criteria were as follows: (1) patients with debilitating VMR refractory to medical therapy and with significant impact on quality of life; (2) negative allergy history and skin testing; and (3) negative computed tomography (CT) scan to rule out skull\u2010base defect or cerebrospinal fluid (CSF) fistula. Patients underwent bilateral vidian neurectomy via a pterygomaxillary approach. Prior to surgery all patients underwent formal ophthalmologic testing to quantify preoperative ocular and lacrimal function. Ophthalmologic testing was repeated postoperatively at approximately 3 months. Patients also completed surveys regarding rhinologic outcomes including the Sinusitis Symptom Questionnaire (SSQ) and the 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022) at the following time points: preoperatively, and 1 week, 4 weeks, 12 weeks, 6 months, 1 year, and 2 years postsurgery. Descriptive statistics and analysis of variance (ANOVA) were undertaken.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven patients (22 sides) underwent bilateral vidian neurectomy with pathologic confirmation of nerve section in all cases. Average follow\u2010up was 19.4 months. Statistically and clinically significant improvement was measured for both the SSQ and the SNOT\u201022 and compared with the patients\u2019 baseline scores (<jats:italic>p<\/jats:italic> &lt; 0.0001). Subscores for rhinorrhea and nasal congestions were also statistically significantly improved (<jats:italic>p<\/jats:italic> &lt; 0.05). No incidence of permanent or measureable dry eye has been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The data suggests that vidian neurectomy is an effective, safe, and definitive treatment for most patients with VMR refractory to medical treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21462","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T14:18:50Z","timestamp":1425305930000},"page":"423-430","source":"Crossref","is-referenced-by-count":28,"title":["Endoscopic vidian neurectomy: a prospective case series"],"prefix":"10.1002","volume":"5","author":[{"given":"Han","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian C.","family":"Micomonaco","sequence":"additional","affiliation":[{"name":"Department of Surgery, Northern Ontario School of Medicine  Thunder Bay Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T.","family":"Dziegielewski","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Florida  Gainesville FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh J.","family":"Sowerby","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezekiel","family":"Weis","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin D.","family":"Wright","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32834dfb52"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200011000-00012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62352-6"},{"key":"e_1_2_7_5_1","first-page":"264","article-title":"Local treatment of aspecific nasal hyperreactivity with capsaicin","volume":"22","author":"Filiaci F","year":"1994","journal-title":"Allergol Immunopathol (Madr)"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100057716"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1482-x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32834e13d8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199103000-00017"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240602000216"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2010.3.4.212"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200102000-00004"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.121022"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00958-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198602000-00012"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1969.00770020544019"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100073394"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.20496"}],"container-title":["International Forum of Allergy &amp; 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