{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:49:02Z","timestamp":1788871742921,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T00:00:00Z","timestamp":1419811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korea Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea","award":["A110893"],"award-info":[{"award-number":["A110893"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"\n Background<\/jats:title>\n Chronic rhinosinusitis (CRS) can be aggravated by viral upper respiratory infections. We aimed to investigate whether any specific human rhinovirus (HRV) serotype is more common in the mucosa of CRS patients, and to find any defining clinical characteristics, according to the various HRV serotypes.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A prospective case\u2010control study was conducted to determine HRV serotypes in 111 CRS patients and 51 non\u2010CRS controls. No participant had a history of upper respiratory infection over a 4\u2010week period. Nasal lavage fluids and turbinate epithelial cells were collected prospectively. When HRV was detected with multiplex polymerase chain reaction (PCR), strains were further characterized by sequencing the VP4\/VP2 region of the HRV genome.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n HRV was detected in 40 CRS subjects (36%) and 11 non\u2010CRS controls (21%). The overall detection rates of HRV in CRS patients were higher than in non\u2010CRS controls (\n p<\/jats:italic>\n < 0.05). Of the 8 serotypes detected in CRS patients, 5 belonged to HRV\u2010A and 3 belonged to HRV\u2010B; HRV\u2010C was not detected. In non\u2010CRS controls, only HRV\u2010A was identified, with only 2 serotypes detected (HRV\u2010A13 and HRV\u2010A16). HRV\u2010B and C were not detected.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The high prevalence of HRV in CRS patients was confirmed in our study. However, we were unable to determine whether certain HRV serotypes are more predominant in CRS patients than non\u2010CRS controls. HRV\u2010A13 was the most common serotype in both CRS patients and non\u2010CRS controls. We could not find any differences in the clinical characteristics according to the HRV serotypes in CRS patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alr.21472","type":"journal-article","created":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T11:58:43Z","timestamp":1419854323000},"page":"197-203","source":"Crossref","is-referenced-by-count":14,"title":["Human rhinovirus serotypes in the nasal washes and mucosa of patients with chronic rhinosinusitis"],"prefix":"10.1002","volume":"5","author":[{"given":"Sung Bu","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Sook","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bong\u2010Jae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Hoon","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Hyun","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Asan Medical Center, University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Ju","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.08.004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/00034894041130S508","article-title":"Etiology of chronic rhinosinusitis: the role of fungus","volume":"193","author":"Hamilos DL","year":"2004","journal-title":"Ann Otol Rhinol Laryngol 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