{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:05:53Z","timestamp":1781525153514,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T00:00:00Z","timestamp":1422835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neo\u2010osteogenesis of the paranasal sinuses is a radiologic finding of unclear clinical significance. Although current evidence suggests that these bony changes represent an inflammatory response rather than an infectious osteitis, bacteria associated with the sinonasal mucosa may induce inflammatory mediators as a mechanism of neo\u2010osteogenesis. The objectives of this study were (1) to determine whether there is an association between bacteria isolated on sinus culture and neo\u2010osteogenesis, and (2) to identify other predictive factors for neo\u2010osteogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ninety patients undergoing sinus surgery for medically refractory CRS were recruited. Radiologic evidence of neo\u2010osteogenesis was assessed by the Global Osteitis Scoring Scale (GOSS) and mucosal disease severity was assessed by the Lund\u2010Mackay score (LMS). Bacterial culture was obtained endoscopically at the preoperative office visit or during surgery. Multiple and logistic regression models were used to evaluate the association between the types of bacterial species isolated, number of previous surgeries, and severity of neo\u2010osteogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty of the 90 (33.3%) patients had radiologic evidence of neo\u2010osteogenesis.\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      was significantly associated with neo\u2010osteogenesis (odds ratio [OR], 3.97; 95% confidence interval [CI], 1.12 to 13.56), whereas\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      was not. The number of previous surgeries, especially 2 or more previous surgeries, was associated with the extent of neo\u2010osteogenesis (OR, 3.48; 95% CI, 1.14 to 10.51). The LMS was also significantly associated with the extent of neo\u2010osteogenesis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The presence of\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      in the sinuses is an independent predictor of neo\u2010osteogenesis, whereas\n                      <jats:italic>S. aureus<\/jats:italic>\n                      is not. The number of previous surgeries and the LMS are also independently associated with the severity of neo\u2010osteogenesis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.21485","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T09:39:44Z","timestamp":1422869984000},"page":"303-309","source":"Crossref","is-referenced-by-count":32,"title":["Clinical predictors of neo\u2010osteogenesis in patients with chronic rhinosinusitis"],"prefix":"10.1002","volume":"5","author":[{"given":"Zhenxiao","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Beijing Tongren Hospital Capital Medical University  Beijing China"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Stanford University School of Medicine  Stanford CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Hajjij","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Stanford University School of Medicine  Stanford CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Affiliated Nanfang Hospital of Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayakar V.","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Beijing Tongren Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Beijing Tongren Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Stanford University School of Medicine  Stanford CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199804000-00008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00020840-200202000-00013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2005.07.007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.04.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.4193\/Rhino10.158","article-title":"Osteitic bone in recalcitrant chronic rhinosinusitis","volume":"49","author":"Videler WJ","year":"2011","journal-title":"Rhinology"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21291"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-008-0038-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24424"},{"key":"e_1_2_7_10_1","first-page":"195","volume-title":"Rhinology: Diseases of the Nose, Sinuses, and Skull Base","author":"Welch KC","year":"2012"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32835ac656"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489409124322"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.06.726"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770005-6"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2010.02218.x"},{"key":"e_1_2_7_17_1","first-page":"249","article-title":"Assessing agreement on classification tasks: the kappa statistic","volume":"2","author":"Carletta J","year":"1996","journal-title":"Comput Linguist"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20068"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.02.025"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3228"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3283350053"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-011-0166-z"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700608"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02838.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00621.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21357"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2857"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21113"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2500\/105065801779954148"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21010"},{"key":"e_1_2_7_31_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.4193\/Rhino09.087","article-title":"Inflammatory cytokines gene expression in bone tissue from patients with chronic rhinosinusitis\u2014a preliminary study","volume":"48","author":"Tuszynska A","year":"2010","journal-title":"Rhinology"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21485","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T16:21:17Z","timestamp":1696609277000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,2]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1002\/alr.21485"],"URL":"https:\/\/doi.org\/10.1002\/alr.21485","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725349443.793505814","asserted-by":"object"}]},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,2]]}}}