{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:38:03Z","timestamp":1761975483461},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T00:00:00Z","timestamp":1425600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>There has been no study investigating nonsteroidal anti\u2010inflammatory drugs (NSAIDs)\u2010exacerbated respiratory disease (NERD) exclusively in childhood. Therefore, in the current study, the authors aimed to evaluate the diagnostic features, clinical characteristics, and follow\u2010up of adolescents diagnosed with NERD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The patients who were consecutively diagnosed with NERD between January 2011, and November 2013, included in the study. Oral provocation test (OPT) with at least 2 different NSAIDs was used to confirm NSAID hypersensitivity in patients with underlying asthma\/chronic rhinosinusitis\/nasal polyps. All patients were followed regularly in 3\u2010month intervals by the Pediatric Allergy and Otorhinolaryngology Department for asthma, allergic rhinitis, or chronic rhinosinusitis with or without nasal polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 10 adolescents with NERD were included in the study. The mean age of the patients at the time of diagnosis was 14.9 \u00b1 1.5 years. Hives or angioedema accompanied respiratory complaints induced by NSAIDs. The mean duration of follow\u2010up was 28.9 \u00b1 12.4 months. All patients had asthma except 1 with asymptomatic bronchial hyperreactivity. Asthma of patients was well\u2010controlled with moderate dose of inhaled corticosteroids. Chronic rhinosinusitis with or without nasal polyps developed in 2 patients. Aspirin desensitization was required in these 2 patients with recurrent nasal polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NERD in childhood has much more favorable clinical characteristics and course than in adulthood. Few adolescents with NERD refer with typical chronic upper respiratory tract complaints. The asthma component seems to be mild and is well controlled in the short\u2010term follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21494","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T14:05:32Z","timestamp":1425650732000},"page":"392-398","source":"Crossref","is-referenced-by-count":17,"title":["Nonsteroidal anti\u2010inflammatory drugs\u2013exacerbated respiratory disease in adolescents"],"prefix":"10.1002","volume":"5","author":[{"given":"Hacer Ilbilge","family":"Ertoy Karagol","sequence":"first","affiliation":[{"name":"Department of Pediatric Allergy and Asthma Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozlem","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy and Asthma Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erdem","family":"Topal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy and Asthma Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alper","family":"Ceylan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arzu","family":"Bakirtas","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy and Asthma Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12260"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.08.035"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.07.004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1542\/peds.56.3.443","article-title":"Aspirin intolerance in chronic childhood asthma: detected by oral challenge","volume":"56","author":"Rachelefsky GS","year":"1975","journal-title":"Pediatrics"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1542\/peds.71.3.313","article-title":"Adverse pulmonary responses to aspirin and acetaminophen in chronic childhood asthma","volume":"71","author":"Fischer TJ","year":"1983","journal-title":"Pediatrics"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12216"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.10.017"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1325618"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12266"},{"key":"e_1_2_6_12_1","unstructured":"Global Initiative for Asthma (GINA).Global Strategy for Asthma Management and Prevention; 2008.http:\/\/www.ginasthma.org\/documents\/4. 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