{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:47:52Z","timestamp":1791301672216,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T00:00:00Z","timestamp":1424995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Sinonasal neuroendocrine carcinoma (SNEC) is a rare, aggressive tumor usually associated with a poor prognosis. This study analyzes the clinicopathological characteristics and survival outcomes of SNEC using population\u2010based data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Surveillance, Epidemiology, and End Results (SEER) database (1973 to 2011) was queried for SNEC cases. Data analyzed included patient demographics, incidence, treatment modality, and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 201 cases of SNEC were identified. Mean age at diagnosis was 55.8 \u00b1 15.7 years. Overall 5\u2010year disease\u2010specific survival (DSS) rate for SNEC was 50.8%. Five\u2010year survival analysis for SNEC by site revealed DSS of 80.7%, 59.2%, 34.5%, and 33.0% for the sphenoid sinus, nasal cavity, maxillary sinus, and ethmoid sinus, respectively (<jats:italic>p<\/jats:italic> = 0.0014). Cox proportional hazard analysis revealed greater hazard of death for the maxillary (hazard ratio [HR] 2.14; 95% confidence interval [CI], 1.21 to 3.71; <jats:italic>p<\/jats:italic> = 0.0094) and ethmoid sinuses (HR 1.83; 95% CI, 1.05 to 3.16; <jats:italic>p<\/jats:italic> = 0.0345) when compared to the nasal cavity. Advanced stage disease (stages III to IV, 5\u2010year DSS 40.5%, <jats:italic>p<\/jats:italic> = 0.0008) was associated with poor survival outcomes. Survival was better among those treated with surgery (with [59.4%] or without [69.0%] radiotherapy) than those treated with primary radiotherapy alone (39.9%) (<jats:italic>p<\/jats:italic> &lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SNEC commonly presents at an advanced\u2010stage with poor survival outcomes. Negative prognostic factors include primary tumor site and advanced stage disease. SNEC is a highly aggressive tumor necessitating surgery and\/or surgery with adjuvant radiotherapy as the treatment of choice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21497","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T19:46:56Z","timestamp":1425066416000},"page":"448-453","source":"Crossref","is-referenced-by-count":56,"title":["Sinonasal neuroendocrine carcinoma: a population\u2010based analysis of incidence and survival"],"prefix":"10.1002","volume":"5","author":[{"given":"Tapan D.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Vazquez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pariket M.","family":"Dubal","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soly","family":"Baredes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James K.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey Rutgers New Jersey Medical School  Newark NJ"},{"name":"Department of Neurological Surgery Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Anderson","family":"Eloy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey Rutgers New Jersey Medical School  Newark NJ"},{"name":"Department of Neurological Surgery Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880522"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2006.10.024"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21940"},{"key":"e_1_2_6_5_1","volume-title":"World Health Organization classification of tumours: pathology and genetics of head and neck tumours","author":"Barnes L","year":"2005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-3284-3-32"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111000114"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90452-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200010000-00007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10537"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20693"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215106000594"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2006.09.014"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556130808700511"},{"key":"e_1_2_6_15_1","first-page":"1033","article-title":"[Diagnosis and treatment of 11 cases with sinonasal neuroendocrine carcinoma]","volume":"46","author":"Qian GH","year":"2011","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821201)50:11<2388::AID-CNCR2820501126>3.0.CO;2-K"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.59179"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00185390"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20186"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21062"}],"container-title":["International Forum of Allergy &amp; 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