{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:34:33Z","timestamp":1760985273260},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T00:00:00Z","timestamp":1429747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Medical treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP) centers on the administration of steroids. High\u2010dose topical nasal steroids (HDTNS) have shown promising results with less systemic effects than oral steroids. One promising HDTNS is 0.132% dexamethasone nasal spray. We investigated whether intranasal dexamethasone was associated with changes in serum cortisol and\/or intraocular pressure (IOP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with CRSwNP were treated with dexamethasone sodium phosphate 0.132% nasal spray twice daily. Morning serum cortisol and IOP were checked after at least 6 weeks of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010eight patients met study criteria. The average serum cortisol level after at least 6 weeks of therapy (average duration of 38.3 weeks) was 9.8 \u03bcg\/dL (normal range, 4 to 22 \u03bcg\/dL). Ten patients had suppressed cortisol levels (average, 2.5 \u03bcg\/dL). Ten patients underwent IOP measurements and none revealed ocular hypertension on tonometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High\u2010dose dexamethasone nasal spray given for a period of at least 6 weeks does appear to have the potential to cause a decrease in serum cortisol levels; however, future studies with greater power are necessary to support this claim. Additionally, similar administration of high\u2010dose dexamethasone nasal spray did not reveal IOP diagnostic of ocular hypertension on single\u2010measurement tonometry readings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21514","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T05:03:42Z","timestamp":1429851822000},"page":"605-609","source":"Crossref","is-referenced-by-count":16,"title":["Effect of intranasal dexamethasone on endogenous cortisol level and intraocular pressure"],"prefix":"10.1002","volume":"5","author":[{"given":"Benjamin J.","family":"Martino","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Loma Linda University  Loma Linda CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A.","family":"Church","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Loma Linda University  Loma Linda CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin A.","family":"Seiberling","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Loma Linda University  Loma Linda CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480252814199"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3982"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198428020-00002"},{"key":"e_1_2_6_5_1","first-page":"1","article-title":"Local and systemic safety of intranasal corticosteroids","volume":"22","author":"Sastre J","year":"2012","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.110038"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S19885"},{"key":"e_1_2_6_8_1","first-page":"CD006549","article-title":"Topical steroids for nasal polyps","volume":"12","author":"Kalish L","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_9_1","first-page":"100","article-title":"Effect of Pulmicort Respule on rehabilitation after functional endoscopic sinus surgery","volume":"21","author":"Yu C\u2010J","year":"2007","journal-title":"Acta Chimi Sin"},{"key":"e_1_2_6_10_1","first-page":"942","article-title":"The effect of Pulmicort on pediatric chronic sinusitis","volume":"21","author":"Qiao L","year":"2007","journal-title":"Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2008.555"},{"key":"e_1_2_6_12_1","first-page":"821","article-title":"Safety of budesonide in saline sinonasal irrigations in the management of chronic rhinosinusitis with polyposis: lack of significant adrenal suppression","volume":"37","author":"Bhalla RK","year":"2008","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3418"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21228"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540330044033"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21180"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21514","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T05:57:57Z","timestamp":1696571877000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,23]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1002\/alr.21514"],"URL":"https:\/\/doi.org\/10.1002\/alr.21514","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,23]]}}}