{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:21:24Z","timestamp":1761744084234,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T00:00:00Z","timestamp":1425600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004332","name":"Seoul National University Bundang Hospital","doi-asserted-by":"crossref","award":["Grant No. 12-2011-0047"],"award-info":[{"award-number":["Grant No. 12-2011-0047"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Nasal polyposis associated with chronic rhinosinusitis (CRS) is a chronic inflammatory disease that is characterized by infiltration of many inflammatory cells. Meanwhile, interleukin (IL)\u201017A is a well\u2010known proinflammatory cytokine that induces both eosinophilic and neutrophilic inflammation. We investigated the role of IL\u201017A in the development of nasal polyps in the CRS murine model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eosinophilic CRS with nasal polyps was induced by using ovalbumin (OVA) and <jats:italic>Staphylococcus aureus<\/jats:italic> enterotoxin B (SEB) in wild\u2010type BALB\/c and IL\u201017A knockout (KO) mice. Histopathologic changes of the sinonasal cavity were evaluated using hematoxylin and eosin, Periodic acid\u2010Schiff, Sirius red, Masson's trichrome, and immunohistochemistry. The levels of total and OVA\u2010specific immunoglobulin Es (IgEs) in sera were measured using enzyme\u2010linked immunosorbent assay. The expression levels of IL\u20104, IL\u20105, and interferon\u2010\u03b3 (IFN\u2010\u03b3) in the nasal mucosa were assessed by quantitative real\u2010time polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Under the IL\u201017A deficiency, total and OVA\u2010specific IgEs in sera were reduced significantly. Infiltration of both eosinophils and neutrophils into the nasal mucosa, subepithelial fibrosis, and goblet cell count also decreased significantly in IL\u201017A KO mice treated with both OVA and SEB compared with those in the wild\u2010type counterpart. However, there were no significant differences in the number of polypoid lesions among groups. Meanwhile, IL\u20104 increased and IFN\u2010\u03b3 decreased in the nasal mucosa in IL\u201017A KO mice treated with both OVA and SEB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that even though IL\u201017A plays an important role in both nasal inflammation and remodeling, it does not influence the development of nasal polypoid lesions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21515","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T14:14:04Z","timestamp":1425651244000},"page":"363-370","source":"Crossref","is-referenced-by-count":7,"title":["Interleukin\u201017A\u2013induced inflammation does not influence the development of nasal polyps in murine model"],"prefix":"10.1002","volume":"5","author":[{"given":"Sung\u2010Lyong","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Pusan National University Hospital  Busan South 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Center  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang\u2010Heon","family":"Cho","sequence":"additional","affiliation":[{"name":"Graduate School of Immunology Seoul National University College of Medicine  Seoul South Korea"},{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon\u2010Seok","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital  Gyeonggi South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Seoul National University College of Medicine  Seoul South Korea"},{"name":"Department of Otorhinolaryngology Seoul National University Bundang Hospital  Gyeonggi South 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