{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:17:55Z","timestamp":1791231475573,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T00:00:00Z","timestamp":1429747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271054"],"award-info":[{"award-number":["81271054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Oxidative stress is characteristic of chronic airway inflammatory diseases such as asthma, chronic obstructive pulmonary disease and chronic rhinosinusitis with nasal polyps (CRSwNP). Heme oxygenase (HO)\u20101 has been proposed to be a cytoprotective enzyme against oxidative stress in CRSwNP. However, the expression and regulation of HO\u20101 in eosinophilic CRSwNP (ECRS) and non\u2010eosinophilic CRSwNP (non\u2010ECRS) subsets has not been well documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nasal polyps and uncinate process tissues were enrolled from 40 CRSwNP patients (ECRS, 17; non\u2010ECRS, 23) and 20 control subjects, respectively. The messenger RNA (mRNA) and protein expression of HO\u20101 was examined using qRT\u2010PCR, immunohistochemistry, and Western blot staining. Moreover, the stimulatory effects of several cytokines (interferon \u03b3 [IFN\u2010\u03b3], interleukin [IL]\u20105, and IL\u201013, etc.) on HO\u20101 mRNA expression in cultured nasal explants were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mRNA and protein expression of HO\u20101 was significantly increased in polyp tissues compared with healthy controls (<jats:italic>p<\/jats:italic> &lt; 0.05), and the non\u2010ECRS subset showed significantly increased HO\u20101 expression compared with the ECRS subset (<jats:italic>p<\/jats:italic> &lt; 0.05). Moreover, in cultured nasal explant, HO\u20101 mRNA was significantly upregulated in the presence of IFN\u2010\u03b3, IL\u201027, IL\u20105, IL\u201013, and IL\u201017A, but was significantly inhibited by transforming growth factor \u03b21 (TGF\u2010\u03b21) (<jats:italic>p<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that HO\u20101 was differentially expressed and regulated in ECRS and non\u2010ECRS patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21530","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T05:07:52Z","timestamp":1429852072000},"page":"734-740","source":"Crossref","is-referenced-by-count":19,"title":["Expression of heme oxygenase\u20101 in eosinophilic and non\u2010eosinophilic chronic rhinosinusitis with nasal polyps: modulation by cytokines"],"prefix":"10.1002","volume":"5","author":[{"given":"Zhijian","family":"Yu","sequence":"first","affiliation":[{"name":"Allergy Center Otorhinolaryngology Hospital the First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Department of Otolaryngology Head and Neck Surgery Xinhua Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Allergy Center Otorhinolaryngology Hospital the First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Allergy Center Otorhinolaryngology Hospital the First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Xinhua Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingmei","family":"Wu","sequence":"additional","affiliation":[{"name":"Allergy Center Otorhinolaryngology Hospital the First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renqiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Allergy Center Otorhinolaryngology Hospital the First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou 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