{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T10:41:14Z","timestamp":1784371274405,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,13]],"date-time":"2015-06-13T00:00:00Z","timestamp":1434153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Prior investigations into facial pain associated with chronic rhinosinusitis (CRS) have yielded important results, but have yet to use pain\u2010specific outcome measures. This study seeks to characterize facial pain associated with CRS using validated pain\u2010specific instruments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adults with CRS were enrolled into a prospective, cross\u2010sectional study along with control participants presenting with non\u2010CRS diagnoses. Facial pain was characterized in both groups using the Brief Pain Inventory Short Form (BPI\u2010SF) and the Short\u2010Form McGill Pain Questionnaire (SF\u2010MPQ). CRS\u2010specific measures of disease were measured including the 22\u2010item Sino\u2010Nasal Outcome Test\u201022 (SNOT\u201022), nasal endoscopy, and computed tomography scoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients comprised of CRS with nasal polyposis (CRSwNP; n = 25), CRS without nasal polyposis (CRSsNP; n = 30), and control participants (n = 8). Subjects with CRSwNP and CRSsNP were less likely to be pain free than controls (16.0%, 6.7%, and 62.5% respectively, <jats:italic>p<\/jats:italic> = 0.001) and carried greater burden of pain as measured by the BPI\u2010SF and SF\u2010MPQ than controls (<jats:italic>p<\/jats:italic> = 0.002 and <jats:italic>p<\/jats:italic> = 0.017, respectively). Pain in CRS was most commonly located around the eyes and characterized as \u201cthrobbing\u201d and \u201caching.\u201d Nasal polyp status was not associated with differences in character, severity, or location of pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Subjects with CRS have a greater burden of facial pain relative to control subjects across several standardized pain measures. Further, facial pain in CRS significantly correlated to quality of life and CRS\u2010specific disease severity measures. Study across larger cohorts using standardized pain measures is warranted to clarify the association of facial pain with CRS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21539","type":"journal-article","created":{"date-parts":[[2015,6,13]],"date-time":"2015-06-13T09:09:43Z","timestamp":1434186583000},"page":"682-690","source":"Crossref","is-referenced-by-count":31,"title":["Characterization of facial pain associated with chronic rhinosinusitis using validated pain evaluation instruments"],"prefix":"10.1002","volume":"5","author":[{"given":"Adam S.","family":"DeConde","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery, University of California San Diego  San Diego CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess C.","family":"Mace","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Division of Rhinology, Oregon Health and Science University  Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaelene","family":"Ashby","sequence":"additional","affiliation":[{"name":"Sinus and Skull Base Surgery Program, Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery; University of Utah  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Division of Rhinology, Oregon Health and Science University  Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Orlandi","sequence":"additional","affiliation":[{"name":"Sinus and Skull Base Surgery Program, Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery; University of Utah  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremiah A.","family":"Alt","sequence":"additional","affiliation":[{"name":"Sinus and Skull Base Surgery Program, Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery; University of Utah  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/hn.2003.v128.amhn0312811"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino12.000"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240301700106"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.08.003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215106002647"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2001.00514.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin12.087"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.12.048"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31804b1a90"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21408"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24027"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1045"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4637.2003.03002.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(99)00112-6"},{"key":"e_1_2_6_17_1","first-page":"1347","article-title":"Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trial","volume":"28","author":"Thie NM","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(87)91074-8"},{"key":"e_1_2_6_19_1","first-page":"183","article-title":"Staging in rhinosinusitus","volume":"31","author":"Lund VJ","year":"1993","journal-title":"Rhinology"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770005-6"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2856"},{"key":"e_1_2_6_22_1","first-page":"131","article-title":"Mechanisms of the symptoms of rhinosinusitis","volume":"49","author":"Eccles R","year":"2011","journal-title":"Rhinology"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.2978"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989210700104"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23721"},{"key":"e_1_2_6_26_1","first-page":"161","article-title":"The relationship between body posture and pressure in occluded maxillary sinus of man","volume":"27","author":"Falck B","year":"1989","journal-title":"Rhinology"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21217"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.7.705"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.219"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-004-0463-z"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.02.015"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-7-27"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.20.2433"}],"container-title":["International Forum of Allergy &amp; 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