{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:34:51Z","timestamp":1760985291320},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,5,23]],"date-time":"2015-05-23T00:00:00Z","timestamp":1432339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Surprisingly, little literature exists evaluating the optimal duration of antibiotic treatment in \u201cmaximal medical therapy\u201d for chronic rhinosinusitis (CRS). As such, we investigated whether 3 weeks vs 6 weeks of antibiotic therapy resulted in significant differences in clinical response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, randomized cohort study was performed with patients assigned to 3\u2010week or 6\u2010week cohorts. Our primary outcome was failure of \u201cmaximal medical therapy\u201d and surgical recommendation. Secondary outcomes included changes in pretherapy and posttherapy scores for the Rhinosinusitis Disability Index (RSDI), Chronic Sinusitis Survey (CSS), and computed tomography (CT)\u2010based Lund\u2010Mackay (LM) evaluation. Analyses were substratified based on presence of nasal polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty patients were randomized to the 3\u2010week or 6\u2010week treatment cohorts, with near\u2010complete clinical follow\u2010up achieved. No significant difference was found between the proportion of patients who failed medical therapy and were deemed surgical candidates between the 2 cohorts (71% vs 68%, <jats:italic>p<\/jats:italic> = 1.000). No significant difference was found in the change of RSDI or CSS scores in the 3 vs 6 weeks of treatment groups (mean \u00b1 standard error of the mean [SEM]; RSDI: 9.62 \u00b1 4.14 vs 1.53 \u00b1 4.01, <jats:italic>p<\/jats:italic> = 0.868; CSS: 5.75 \u00b1 4.36 vs 9.65 \u00b1 5.34, <jats:italic>p<\/jats:italic> = 0.573). Last, no significant difference was found in the change of LM scores (3.35 \u00b1 1.11 vs 1.53 \u00b1 0.81, <jats:italic>p<\/jats:italic> = 0.829).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on this data, there is little difference in clinical outcomes between 3 weeks vs 6 weeks of antibiotic treatment as part of \u201cmaximal medical therapy\u201d for CRS. Increased duration of antibiotic treatment theoretically may increase risk from side effects and creates higher healthcare costs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21542","type":"journal-article","created":{"date-parts":[[2015,5,23]],"date-time":"2015-05-23T07:42:39Z","timestamp":1432366959000},"page":"820-828","source":"Crossref","is-referenced-by-count":11,"title":["A prospective randomized cohort study evaluating 3 weeks vs 6 weeks of oral antibiotic treatment in the setting of \u201cmaximal medical therapy\u201d for chronic rhinosinusitis"],"prefix":"10.1002","volume":"5","author":[{"given":"Satyan B.","family":"Sreenath","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of North Carolina at Chapel Hill  Chapel Hill NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of North Carolina at Chapel Hill  Chapel Hill NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin D.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of North Carolina at Chapel Hill  Chapel Hill NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily C.","family":"Ambrose","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of North Carolina at Chapel Hill  Chapel Hill NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rounak B.","family":"Rawal","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of North Carolina at Chapel Hill  Chapel Hill NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Charles S.","family":"Ebert","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of North Carolina at Chapel Hill  Chapel Hill NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent A.","family":"Senior","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of North Carolina at Chapel Hill  Chapel Hill NC"},{"name":"Department of Neurosurgery University of North Carolina at Chapel Hill  Chapel Hill NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam M.","family":"Zanation","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of North Carolina at Chapel Hill  Chapel Hill NC"},{"name":"Department of Neurosurgery University of North Carolina at Chapel Hill  Chapel Hill NC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2005.07.003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.3047"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21084"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3334"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1177\/194589240201600605","article-title":"A retrospective analysis of treatment outcomes and time to relapse after intensive medical treatment for chronic sinusitis","volume":"16","author":"Subramanian HN","year":"2002","journal-title":"Am J Rhinol 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