{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:34:30Z","timestamp":1780371270264,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T00:00:00Z","timestamp":1430956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Sinonasal extramedullary plasmacytoma (SN\u2010EMP) is a rare plasma cell neoplasm. Published literature on this tumor largely consists of case reports and case\u2010series with small sample sizes. This study analyzed population\u2010based data on SN\u2010EMP patients to understand demographic and clinical features as well as incidence and survival trends.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Surveillance, Epidemiology, and End Results (SEER) database was queried for SN\u2010EMP and other head and neck EMP (HN\u2010EMP) cases from 1973 to 2011. Cases were analyzed to determine patient demographics, initial treatment modality, and survival outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 778 patients identified with EMP in the head and neck region, 367 patients had SN\u2010EMP and 411 had other HN\u2010EMP. There was a strong male predilection found, with a male\u2010to\u2010female ratio of 3.65:1 in the SN\u2010EMP group and 1.87:1 in the other HN\u2010EMP group. The majority of the patients presented with localized disease in both SN\u2010EMP (84.4%) and other HN\u2010EMP (81.0%) groups. The most common treatment modality reported in this database was surgery with adjuvant radiotherapy in both SN\u2010EMP (46.3%) and other HN\u2010EMP (38.9%) groups, followed by radiotherapy alone (SN\u2010EMP: 40.7%; other HN\u2010EMP: 34.2%). Five\u2010year and 10\u2010year disease\u2010specific survival rates were comparable between SN\u2010EMP (88.2% and 83.3%, respectively) and other HN\u2010EMP (90.0% and 87.4%, respectively) (<jats:italic>p<\/jats:italic> = 0.6016 and <jats:italic>p<\/jats:italic> = 0.4015, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study analyzed the largest cohort of SN\u2010EMP patients to date. There was no statistically significant survival advantage found for any 1 particular treatment modality over other treatment modalities in both SN\u2010EMP and other HN\u2010EMP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21544","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T09:29:05Z","timestamp":1430990945000},"page":"862-869","source":"Crossref","is-referenced-by-count":30,"title":["Sinonasal extramedullary plasmacytoma: a population\u2010based incidence and survival analysis"],"prefix":"10.1002","volume":"5","author":[{"given":"Tapan D.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moaz M.","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kam","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soly","family":"Baredes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"},{"name":"Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Anderson","family":"Eloy","sequence":"additional","affiliation":[{"name":"Department of 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