{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:21:50Z","timestamp":1771550510253,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T00:00:00Z","timestamp":1433462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministry of Health of the Czech Republic","doi-asserted-by":"crossref","award":["IGA MZCR NT13500-4\/2012"],"award-info":[{"award-number":["IGA MZCR NT13500-4\/2012"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to determine the severity of extraesophageal reflux (EER) in patients with various degrees of chronic rhinosinusitis (CRS), and particularly in patients with simultaneous bronchial asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with different severity of CRS were invited to participate in the study. Group I consisted of patients with CRS without nasal polyps or bronchial asthma; group II consisted of patients with CRS with nasal polyps but without bronchial asthma; group III consisted of patients with CRS with nasal polyps and bronchial asthma. The age, gender, Reflux Symptom Index, severity of EER evaluated using the Restech system, and number of previous functional endoscopic sinus surgeries (FESSs) were compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 90 patients (30 in each group) were recruited for the study. Pathological EER was significantly often present in group III when compared with group I and group II in all parameters analyzed (RYAN score, number of EER episodes, total percentage of time below pH 5.5). Furthermore, patients from group III had undergone more surgeries in the past.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with CRS with nasal polyps and simultaneous bronchial asthma suffer from significant EER. Antireflux therapy can be recommended for these patients. However, the effect has to be confirmed in further studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21560","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T13:05:33Z","timestamp":1433509533000},"page":"944-949","source":"Crossref","is-referenced-by-count":10,"title":["Patients with chronic rhinosinusitis and simultaneous bronchial asthma suffer from significant extraesophageal reflux"],"prefix":"10.1002","volume":"5","author":[{"given":"Karol","family":"Zelen\u00edk","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University Hospital Ostrava  Ostrava Czech Republic"},{"name":"Faculty of Medicine University of Ostrava  Ostrava Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Matou\u0161ek","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University Hospital Ostrava  Ostrava Czech Republic"},{"name":"Faculty of Medicine University of Ostrava  Ostrava Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Form\u00e1nek","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Ostrava  Ostrava Czech Republic"},{"name":"Department of Gastroenterology V\u00edtkovice Hospital  Ostrava Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ond\u0159ej","family":"Urban","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Ostrava  Ostrava Czech Republic"},{"name":"Department of Gastroenterology V\u00edtkovice Hospital  Ostrava Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Kom\u00ednek","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University Hospital Ostrava  Ostrava Czech Republic"},{"name":"Faculty of Medicine University of Ostrava  Ostrava Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894041130S502"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/hn.2003.v128.amhn0312811"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-004-0027-z"},{"key":"e_1_2_6_5_1","first-page":"303","article-title":"Resistant rhinosinusitis: what to do when usual measures fail","volume":"24","author":"Slavin RG.","year":"2003","journal-title":"Allergy Asthma Proc"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21423"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.4193\/Rhino13.053","article-title":"Bacterial biofilms in patients with chronic rhinosinusitis: a confocal scanning laser microscopy study","volume":"52","author":"Danielsen KA","year":"2014","journal-title":"Rhinology"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2012.06.004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000163751.00885.63"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.123857"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2500\/105065899781389777"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0022-1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318165e324"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.7.831"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200409000-00015"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2849"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.08.039"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05598.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556130608500314"},{"issue":"23","key":"e_1_2_6_20_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2012","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol Suppl"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.5.1490"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.1.9907072"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-10-49"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e328332ca2f"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(02)00097-8"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-009-0915-6"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000191463.67692.36"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2013.11.007"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e32833adc8d"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21147"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.116"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753465810384606"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/736486"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.08.022"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941011900808"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12237"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.18"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2007.12.005"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940911800302"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21560","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21560","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T14:55:07Z","timestamp":1695912907000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,5]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1002\/alr.21560"],"URL":"https:\/\/doi.org\/10.1002\/alr.21560","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,5]]}}}