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The purpose of this work is to provide a range of effective SLIT dosing based upon a rigorous review of the existing evidence base. An appendix with SLIT dosing recommendations is also included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive search of the past 25 years of the medical literature using PubMed was performed for specific antigens. Inclusion criteria for articles included: randomized, placebo\u2010controlled studies of SLIT, studies with clinical allergic rhinitis outcomes, and dosing units available to determine the micrograms per month of major allergen administered. The extracted data was used to compile a range of effective SLIT dosing for individual antigens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010five articles met the inclusion criteria, providing a range of effective dosing for some allergens. There was commonly a wide range in doses for particular antigens between the individual studies. For some antigens, there was significant overlap in dosage amount between studies showing efficacy and lack of efficacy. Clinical trials meeting inclusion criteria are not available for many allergens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provided a comprehensive review of the published sublingual dosing ranges for specific antigens. The review provided a range of effective sublingual doses for some allergens, whereas for other allergens there was insufficient published data to determine specific doses. Recommendations for SLIT dosing were produced based on the data revealed in the review and expert opinion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21561","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T17:48:01Z","timestamp":1434736081000},"page":"773-783","source":"Crossref","is-referenced-by-count":20,"title":["Dosing of <i>s<\/i>ublingual immunotherapy for allergic rhinitis: evidence\u2010based review with recommendations"],"prefix":"10.1002","volume":"5","author":[{"given":"Bryan D.","family":"Leatherman","sequence":"first","affiliation":[{"name":"Coastal Sinus and Allergy Center  Gulfport MS"},{"name":"Coastal Ear Nose and Throat Associates  Gulfport MS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Khalid","sequence":"additional","affiliation":[{"name":"Massachusetts Eye And Ear Infirmary  Boston 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