{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:39:52Z","timestamp":1789810792712,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T00:00:00Z","timestamp":1434585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Natural Science Foundations of Shanghai","award":["12ZR1425300"],"award-info":[{"award-number":["12ZR1425300"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Glucocorticosteroids (GCs) are highly effective in mitigating allergic inflammation. In this study, we investigate the effects of dexamethasone (DEX) on regulatory T cells (Tregs) in a murine model of allergic rhinitis (AR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>BALB\/c mice were sensitized to ovalbumin (OVA) followed by intranasal OVA challenge. Mice in the treatment group received DEX by intraperitoneal injection (5 mg\/kg\/day) 1 hour before the OVA challenge. Further, CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>\u2212<\/jats:sup> T cells from the spleens were cultured in presence of DEX. The effects of DEX on CD4<jats:sup>+<\/jats:sup>Foxp3<jats:sup>+<\/jats:sup> T cells were then assessed in vivo as well as in vitro.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Frequencies of sneezing and scratching decreased significantly in the DEX\u2010treated group compared to that in the OVA group. Histopathological analyses showed that DEX restored the destroyed and discontinuous ciliated epithelium of the nasal mucosa in the OVA group. Moreover, DEX inhibited the production of interleukin (IL)\u20104, IL\u20105, and IL\u201013 in the nasal cavity lavage fluid in this group. We also observed a significant increase in the percentage of CD4<jats:sup>+<\/jats:sup>Foxp3<jats:sup>+<\/jats:sup> T cells in the OVA group. In vivo, DEX treatment significantly decreased the number of CD4<jats:sup>+<\/jats:sup>Foxp3<jats:sup>+<\/jats:sup> T cells. However, in vitro, the proportion of these cells increased in the presence of DEX. Furthermore, the number of late stage apoptotic CD4<jats:sup>+<\/jats:sup> T cells was also significantly increased upon exposure to DEX.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DEX therapy effectively suppresses AR symptoms, but does not result in the expected increase in the frequency of Tregs in vivo. Thus, whether GCs exert immunosuppressive effects by influencing the number of Tregs remains unresolved.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21579","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T11:07:18Z","timestamp":1434625638000},"page":"900-906","source":"Crossref","is-referenced-by-count":21,"title":["Dexamethasone suppresses allergic rhinitis and amplifies CD4<sup>+<\/sup>Foxp3<sup>+<\/sup> regulatory T cells in vitro"],"prefix":"10.1002","volume":"5","author":[{"given":"Weihua","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai East Hospital, Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Shanghai East Hospital, Tongji University School of Medicine  Shanghai 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