{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T08:16:48Z","timestamp":1782548208049,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T00:00:00Z","timestamp":1437523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Allergic rhinitis (AR) and antihistamine usage can cause xerostomia. The study aims to examine if AR, antihistamines, and the use of antihistamines in AR have histopathological effects on the submandibular gland. The study also investigates the effect of oxidant and antioxidant plasma parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two adult Sprague\u2010Dawley rats were used in the study. The rats were divided into the 4 following groups: the control group (C group); the AR group; an antihistamine\u2010treated group (AH group); and an AR plus antihistamine\u2010treated group (AR+AH group). The AR and AR+AH groups were sensitized using ovalbumin. The AR+AH and AH groups received desloratadine. The histopathological effects of AR and desloratadine treatment on the submandibular glands (SMGs) and the values of the oxidative and antioxidative serum parameters were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histopathological examination of sections of the SMGs from the AR and AH groups revealed that vacuolization was present in the mucous acinar and ductal cells and that the number of connective\u2010tissue cells was greater than that of the control group. The appearances of the AR+AH\u2013group sections were similar to those of the control group. The superoxide dismutase activity level and the glutathione level were relatively decreased in these groups compared with those of the control group. The malondialdehyde level in the AR group was increased compared with that of the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The AR\u2010induced pathological changes were diminished by desloratadine treatment. Thus, the new\u2010generation antihistamine desloratadine may be used to treatment of AR patients who have xerostomia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21589","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T06:40:51Z","timestamp":1437547251000},"page":"1164-1169","source":"Crossref","is-referenced-by-count":10,"title":["Effects of allergic rhinitis and desloratadine on the submandibular gland in a rat allergy model"],"prefix":"10.1002","volume":"5","author":[{"given":"Arzu","family":"Tatar","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Medical Faculty, Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Secil Nazife","family":"Parlak","sequence":"additional","affiliation":[{"name":"Department of Embryology and Histology Medical Faculty, Ataturk University  Erzurum 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