{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T22:27:51Z","timestamp":1777328871420,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T00:00:00Z","timestamp":1436313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hefei Industrial Pharmaceutical Institute Co., Ltd., Hefei, China; and China Pharmaceutical University (CPU), Nanjing, China"},{"name":"China Govt. Scholarship-Chinese University Program for the international students borne by the China Scholarship Council","award":["# 2013GXZB28"],"award-info":[{"award-number":["# 2013GXZB28"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Allergic rhinitis (AR) is a very common worldwide problem; patients display a number of symptoms, such as sneezing, nasal itching, and rhinorrhea, and their lifestyle is affected. Desloratadine is a novel, long\u2010acting inhibitor of histamine. However, very little is known about the effect of desloratadine citrate disodium injection (DLC injection) on AR, and the underlying mechanisms are yet unexplored. Herein, we sought to explore the effects and mechanisms of actions of DLC injection in ovalbumin (OVA)\u2010induced immune responses in a rat model of AR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty rats were subjected to immunization with OVA (intraperitoneal [IP]), followed by a nasal challenge with OVA. Drugs or saline were given daily for treatment. Nasal symptoms and histology of the nasal mucosa were examined. Cytokines such as interleukin (IL)\u20104, IL\u201012, interferon (IFN)\u2010\u03b3, adhesion molecules such as soluble vascular cell adhesion molecule 1 (sVCAM\u20101), and inducible nitric oxide synthase (iNOS) expression were assessed by enzyme\u2010linked immunosorbent assay (ELISA) kit. Nitric oxide (NO) concentration was also measured by NO assay kit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DLC treatment (intravenous [IV]) significantly decreased the frequency of sneezing and nasal scratching and alleviated nasal inflammation by increasing the serum levels of IFN\u2010\u03b3 and IL\u201012, while lowering the expression of IL\u20104. Thus, DLC (IV) treatment led to a marked elevation in T\u2010helper 1\/T\u2010helper 2 (Th1\/Th2) ratio when administered in the AR rats. The expression of sVCAM\u20101, iNOS, and NO were also reversed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DLC (IV), given after an allergen challenge, improved Th1 cytokines level and restrained Th2 responses alleviating the symptoms of AR. Our results indicate that DLC injection may exhibit such effects through the modulation of T\u2010cell responses.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21594","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T06:16:28Z","timestamp":1436336188000},"page":"1170-1176","source":"Crossref","is-referenced-by-count":7,"title":["Effects of desloratadine citrate disodium injection on rat models of ovalbumin\u2010induced allergic rhinitis: involvement of T\u2010cell responses modulation"],"prefix":"10.1002","volume":"5","author":[{"given":"Xin","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Physiology, China Pharmaceutical University  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arijit","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, China Pharmaceutical University  Nanjing Jiangsu 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