{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T05:59:08Z","timestamp":1718863148705},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T00:00:00Z","timestamp":1438819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In clinical practice, it is fundamental to distinguish between sensitization and allergy, mainly with respect to polysensitized patients. The aim of this study was to evaluate whether serum immunoglobulin E (IgE) to white birch (<jats:italic>Betula verrucosa<\/jats:italic>) pollen antigen (Bet v 1) assessment might be able to differentiate simple sensitization from true allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 197 subjects (100 females; mean age 44.9 years) with serum Bet v 1 IgE positivity and history of nasal symptoms were evaluated. Subjects were subdivided in 2 groups: allergic and sensitized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Allergic patients were 58.4% of the total; they had higher serum Bet v 1 IgE levels than sensitized subjects (<jats:italic>p<\/jats:italic> &lt; 0.001). A serum IgE to Bet v 1 value &gt;8.94 kilo units of allergen per liter (kUA\/L) was able to differentiate between sensitization and allergy (area under the receiver operating characteristic curve [AUC] = 0.76; diagnostic odds ratio, ie, degree of agreement between health status and dichotomized IgE levels [DOR] = 6.5). Gender and season when the blood was drawn influenced IgE levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum Bet v 1 IgE measurement may be able to differentiate sensitization from allergy in subjects with sensitization to <jats:italic>Betulaceae<\/jats:italic> pollen allergens. Thus, Bet v 1 IgE measurement should be considered a useful step in the management of patients with allergic rhinitis due to <jats:italic>Betulaceae<\/jats:italic> pollen allergens.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21612","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T18:31:14Z","timestamp":1438885874000},"page":"1151-1155","source":"Crossref","is-referenced-by-count":3,"title":["Can serum white birch (<i>Betula verrucosa<\/i>) pollen antigen (Bet v 1) immunoglobulin E measurement distinguish between sensitization and allergy?"],"prefix":"10.1002","volume":"5","author":[{"given":"Giorgio","family":"Ciprandi","sequence":"first","affiliation":[{"name":"Allergy Department National Institute For Cancer Research\u2013University Hospital, Istituto di Ricovero e Cura a Carattere Scientifico \u2013 Azienda Ospedaliera Universitaria (IRCCS\u2010AOU) San Martino  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Comite","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine IRCCS\u2010AOU San Martino  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Ferrero","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine IRCCS\u2010AOU San Martino  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Minale","sequence":"additional","affiliation":[{"name":"Allergy Department National Institute For Cancer Research\u2013University Hospital, Istituto di Ricovero e Cura a Carattere Scientifico \u2013 Azienda Ospedaliera Universitaria (IRCCS\u2010AOU) San Martino  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Voltolini","sequence":"additional","affiliation":[{"name":"Allergy Department National Institute For Cancer Research\u2013University Hospital, Istituto di Ricovero e Cura a Carattere Scientifico \u2013 Azienda Ospedaliera Universitaria (IRCCS\u2010AOU) San Martino  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donatella","family":"Bignardi","sequence":"additional","affiliation":[{"name":"Allergy Department National Institute For Cancer Research\u2013University Hospital, Istituto di Ricovero e Cura a Carattere Scientifico \u2013 Azienda Ospedaliera Universitaria (IRCCS\u2010AOU) San Martino  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Fontana","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit; IRCCS\u2010AOU San Martino  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Bruzzone","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit; IRCCS\u2010AOU San Martino  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costantino","family":"Troise","sequence":"additional","affiliation":[{"name":"Allergy Department National Institute For Cancer Research\u2013University Hospital, Istituto di Ricovero e Cura a Carattere Scientifico \u2013 Azienda Ospedaliera Universitaria (IRCCS\u2010AOU) San Martino  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Mussap","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine IRCCS\u2010AOU San Martino  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.12.1071"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1056\/NEJMcp1412282","article-title":"Allergic rhinitis","volume":"172","author":"Wheatley LM","year":"2015","journal-title":"N Engl J Med"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02728.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.05.017"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2011.05.009"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2500\/ar.2013.4.0061"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463201002300438"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2012.09.002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12530"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.02.024"},{"issue":"10","key":"e_1_2_7_12_1","first-page":"22","article-title":"Skin tests used in type 1 allergy testing. 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