{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:45:23Z","timestamp":1788281123825,"version":"build-2803163510"},"reference-count":86,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T00:00:00Z","timestamp":1442275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Management strategies employed for cases of cerebrospinal fluid (CSF) rhinorrhea vary widely because of limited evidence\u2010based guidance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review of the literature was performed using PubMed, EMBASE, and Cochrane databases from January 1990 through September 2014 to examine 5 endoscopic repair techniques and 8 perioperative management strategies for CSF rhinorrhea. Benefit\u2010harm assessments, value judgments, and recommendations were made based on the available evidence. Study exclusion criteria were language other than English, pre\u20101990 studies, case reports, and nonrhinologic leak. All authors agreed on recommendations through an iterative process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We reviewed 67 studies examining 13 practices pertinent to the management of CSF rhinorrhea, reaching a highest aggregate grade of evidence of B. The literature does not support the routine use of prophylactic antibiotics or lumbar drainage. Various endoscopic repair materials show similar success rates; however, larger defects may benefit from vascularized grafts. There were no relevant studies to address postoperative activity restrictions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite relatively low levels of evidence, recommendations for the management of CSF rhinorrhea can be made based on the current literature. Higher\u2010level studies are needed to better determine optimal clinical management approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.21627","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T05:30:51Z","timestamp":1442295051000},"page":"17-24","source":"Crossref","is-referenced-by-count":99,"title":["Management of cerebrospinal fluid rhinorrhea: an evidence\u2010based review with recommendations"],"prefix":"10.1002","volume":"6","author":[{"given":"Gretchen M.","family":"Oakley","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery University of Utah School of Medicine  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Orlandi","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery University of Utah School of Medicine  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford A.","family":"Woodworth","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery University of Alabama  Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pete S.","family":"Batra","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rush University  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremiah A.","family":"Alt","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery University of Utah School of Medicine  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2004.101.5.0757"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/02688699008992759"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-001-0059-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200007000-00019"},{"key":"e_1_2_6_6_1","first-page":"277","article-title":"Closure of cerebrospinal fluid leaks prevents ascending bacterial meningitis","volume":"43","author":"Bernal\u2010Sprekelsen M","year":"2005","journal-title":"Rhinology"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814520685"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22475"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20095"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","unstructured":"Oxford Centre for Evidence\u2010based Medicine (CEBM).Levels of Evidence. 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