{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:08:02Z","timestamp":1765825682452,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T00:00:00Z","timestamp":1454371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000125","name":"National Institute of Occupational Safety and Health","doi-asserted-by":"crossref","award":["T420H008428"],"award-info":[{"award-number":["T420H008428"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Airplane cabin supply air has been shown to contain multiple possible respiratory irritants. In addition, changes in barometric pressure in flight may contribute to specific respiratory conditions. Therefore, there may be an association between commercial airline flight and sinus disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants of the Secondhand\u2010Smoke, Air Quality and Respiratory Health Among Flight Attendants Study were administered an online questionnaire pertaining to their flight experience and respiratory health. Working years, working days per month, and number of trips per month were quantified, as well as smoking exposure and self\u2010reported physician diagnoses of sinusitis, asthma, and rhinitis. The sinonasal outcomes were quantified using a Respiratory Questionnaire Survey (RQS) score. Multivariable analyses were performed to evaluate the associations between flight time and sinus disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 579 participants met the inclusion criteria for this study, with cohort prevalence of sinusitis, asthma, and rhinitis of 25.3%, 14.4%, and 20.5%, respectively. Tertiles 2 and 3 of working days per month were associated with higher RQS scores compared to tertile 1 (<jats:italic>p<\/jats:italic> for trend &lt;0.01). Individual symptoms significantly associated with increasing number of working days per month included \u201cneed to blow nose,\u201d \u201csneezing,\u201d and \u201cthick nasal discharge,\u201d and the number of international trips per month was significantly associated with \u201ccoughing\u201d and \u201cfacial pain and pressure,\u201d among other symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the largest study to analyze the relations between airline flight time and sinonasal disease. The results suggest a possible association between sinusitis diagnosis, symptom scores, and specific sinonasal symptoms, and airline flight time.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21647","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T07:56:49Z","timestamp":1454399809000},"page":"437-444","source":"Crossref","is-referenced-by-count":3,"title":["The association between airline flight and sinonasal symptoms"],"prefix":"10.1002","volume":"6","author":[{"given":"Josef","family":"Shargorodsky","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins University School of Medicine  Baltimore MD"},{"name":"Coastal Ear Nose and Throat  Neptune NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences Johns Hopkins University Bloomberg School of Public Health  Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances","family":"Stillman","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences Johns Hopkins University Bloomberg School of Public Health  Baltimore MD"},{"name":"Welch Center for Prevention, Epidemiology, and Clinical Research Johns Hopkins Medical Institutions  Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Soong","sequence":"additional","affiliation":[{"name":"Department of Health Behavior and Society Johns Hopkins University Bloomberg School of Public Health  Baltimore MD"},{"name":"Institute for Global Tobacco Control Johns Hopkins University Bloomberg School of Public Health  Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Navas\u2010Acien","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences Johns Hopkins University Bloomberg School of Public Health  Baltimore MD"},{"name":"Welch Center for Prevention, Epidemiology, and Clinical Research Johns Hopkins Medical Institutions  Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Reh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins University School of Medicine  Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894041130S502"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/1047322X.1998.10390150"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-6-28"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00405416"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/b107243"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0b013e3181a7f048"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/tobaccocontrol\u20102013\u2010051364"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1515\/REVEH.2002.17.1.1"},{"key":"e_1_2_6_10_1","first-page":"1","volume-title":"Scott\u2010Brown's otorhinolaryngology, head and neck surgery","author":"Benson AJ","year":"2008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215110002331"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3357\/ASEM.2513.2009"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.121022"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000157693.92975.02"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21232"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23037"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001611"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0668.2007.00482.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000130264.66211.74"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1500ED"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.12.989"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-13-13"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2190\/HS.38.2.f"},{"key":"e_1_2_6_24_1","unstructured":"Bureau of Labor Statistics U.S. Department of Labor Occupational Outlook Handbook 2014\u201315 Edition Flight Attendants.http:\/\/www.bls.gov\/ooh\/transportation\u2010and\u2010material\u2010moving\/flight\u2010attendants.htm. Accessed August 29 2015."}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21647","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:11:04Z","timestamp":1696605064000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,2]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1002\/alr.21647"],"URL":"https:\/\/doi.org\/10.1002\/alr.21647","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"type":"print","value":"2042-6976"},{"type":"electronic","value":"2042-6984"}],"subject":[],"published":{"date-parts":[[2016,2,2]]}}}