{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:45:24Z","timestamp":1793915124211,"version":"4.8.0"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T00:00:00Z","timestamp":1454371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Montelukast is used in the treatment of allergic rhinitis and asthma. It has been used as adjuvant therapy in patients with chronic rhinosinusitis (CRS), but its effectiveness has not been evaluated. This study evaluates the efficacy of adjuvant leukotriene receptor antagonism in CRS and subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of collected data at a tertiary\u2010referral institution. We identified all patients who were prescribed montelukast postoperatively and had a lapse in therapy for at least 1 month (n = 50), so that the patients themselves serve as their own control group. Twenty\u2010item Sino\u2010Nasal Outcomes Test (SNOT\u201020) scores and Lund\u2010Kennedy endoscopy scores were obtained for each patient. Scores were compared with and without montelukast using Wilcoxon signed rank test. The analysis was controlled for changes in other medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010two therapy lapses were identified in 50 patients. Twenty\u2010seven patients had eosinophilic CRS with polyps (eCRSwNP), 8 had Samter's triad (ST), and 15 had allergic fungal sinusitis (AFS). Overall mean follow\u2010up was 46.5 months. Overall, SNOT\u201020 scores and endoscopy scores were significantly lower with montelukast (<jats:italic>p<\/jats:italic> &lt; 0.005 for both). On subgroup analysis, SNOT\u201020 scores were significantly improved for patients with eCRSwNP and AFS (<jats:italic>p<\/jats:italic> &lt; 0.001 and <jats:italic>p<\/jats:italic> = 0.001, respectively). Endoscopy scores were significantly improved for patients with eCRSwNP (<jats:italic>p<\/jats:italic> = 0.044). Outcomes approached, but did not reach, significance for patients with ST (<jats:italic>p<\/jats:italic> = 0.123 for SNOT\u201020 and <jats:italic>p<\/jats:italic> = 0.146 for endoscopy). There was also significant improvements in patients with asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The addition of montelukast as postoperative therapy may be beneficial for patients with eCRSwNP and AFS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21649","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T07:56:43Z","timestamp":1454399803000},"page":"243-247","source":"Crossref","is-referenced-by-count":21,"title":["Effectiveness of leukotriene receptor antagonism in the postoperative management of chronic rhinosinusitis"],"prefix":"10.1002","volume":"6","author":[{"given":"Joshua C.","family":"Yelverton","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Georgia Regents University  Augusta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Georgia Regents University  Augusta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Georgia Regents University  Augusta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilo Reyes","family":"Gelves","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Hospital General de Medellin  Medellin Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stilianos E.","family":"Kountakis","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Georgia Regents University  Augusta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.2.357"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198406213102502"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1986.tb01960.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199012203232506"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24477"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.121022"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510410s02"},{"key":"e_1_2_6_9_1","first-page":"183","article-title":"Staging in rhinosinusitus","volume":"31","author":"Lund VJ","year":"1993","journal-title":"Rhinology"},{"key":"e_1_2_6_10_1","first-page":"51","article-title":"Anti\u2010inflammatory properties of montelukast, a leukotriene receptor antagonist in patients with asthma and nasal polyposis","volume":"21","author":"Sch\u00e4per C","year":"2011","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753465811427577"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.01160.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.07.010"},{"key":"e_1_2_6_14_1","first-page":"142","article-title":"Effects of leukotriene receptor antagonist therapy in patients with chronic rhinosinusitis in a real life rhinology clinic setting","volume":"39","author":"Wilson AM","year":"2001","journal-title":"Rhinology"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(03)00359-0"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21649","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T20:09:37Z","timestamp":1696622977000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,2]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1002\/alr.21649"],"URL":"https:\/\/doi.org\/10.1002\/alr.21649","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,2]]}}}