{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:56:49Z","timestamp":1790726209956,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T00:00:00Z","timestamp":1447286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Over 550,000 sinus surgeries are performed annually in the United States on patients with chronic rhinosinusitis (CRS). Although the results of sinus surgery vary widely, no known genetic factor has been identified to predict surgical outcomes. The bitter taste receptor T2R38 has recently been demonstrated to regulate upper airway innate defense and may affect patient responses to therapy. Our goal was to determine whether\n                      <jats:italic>TAS2R38<\/jats:italic>\n                      genetics predicts outcomes in CRS patients following sinus surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective study of patients undergoing sinus surgery evaluating postoperative outcomes through the 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022). Patients were genotyped for\n                      <jats:italic>TAS2R38<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 123 patients with CRS were initially analyzed; 82 patients showed nasal polyps (CRSwNP) and 41 patients were without nasal polyps (CRSsNP). Six months after surgery, the overall SNOT\u201022 improvement was 25 \u00b1 23 points. The\n                      <jats:italic>TAS2R38<\/jats:italic>\n                      genotype was found to significantly correlate with surgical outcomes in patients without polyps; homozygotes for the functional receptor had a mean improvement of 38 \u00b1 21, whereas heterozygotes or homozygotes for the nonfunctional receptor had a mean improvement of 12 \u00b1 22 (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.006). This result was confirmed with a multivariate regression that incorporated further patients with 1\u2010month and 3\u2010month scores (n = 207).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients undergoing sinus surgery for CRS, we have identified a genetic polymorphism that predicts variability in quality of life improvement following surgery at 6 months in nonpolypoid CRS. This is the first genetic polymorphism identified that has demonstrated to predict surgical outcome for a select group of CRS patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.21666","type":"journal-article","created":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T14:18:41Z","timestamp":1447337921000},"page":"25-33","source":"Crossref","is-referenced-by-count":106,"title":["<i>TAS2R38<\/i>\n                    genotype predicts surgical outcome in nonpolypoid chronic rhinosinusitis"],"prefix":"10.1002","volume":"6","author":[{"given":"Nithin D.","family":"Adappa","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery The University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Farquhar","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery The University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James N.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery The University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery The University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel","family":"Doghramji","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery The University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane A.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery The University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Owens","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery The University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrine","family":"Mansfield","sequence":"additional","affiliation":[{"name":"Monell Chemical Senses Center  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lysenko","sequence":"additional","affiliation":[{"name":"Monell Chemical Senses Center  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery The University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly J.","family":"Cowart","sequence":"additional","affiliation":[{"name":"Monell Chemical Senses Center  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle R.","family":"Reed","sequence":"additional","affiliation":[{"name":"Monell Chemical Senses Center  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam A.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery The University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,12]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"National Ambulatory Medical Care Survey: 2000 summary","volume":"328","author":"Cherry DK","year":"2002","journal-title":"Adv Data"},{"issue":"205","key":"e_1_2_7_3_1","first-page":"1","article-title":"Summary health statistics for U.S. adults: National 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