{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T09:46:52Z","timestamp":1785750412650,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T00:00:00Z","timestamp":1450310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis (CRS) is very prevalent in the cystic fibrosis (CF) patient population, and leads to high morbidity and markedly decreased quality of life (QOL). Identification of genetic markers that contribute to CRS symptoms in these patients can allow for risk stratification and tailoring of medical and surgical treatments. T2R38 is a bitter taste receptor expressed in the sinonasal tract, and nonfunctional alleles of this receptor have been implicated in treatment\u2010refractory CRS in non\u2010CF patients. The purpose of this study is to investigate the significance of T2R38 genotype in the variability of sinonasal QOL and CRS disease severity in a sample of CF patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>\u0394F508 homozygous CF patients were recruited from the University of Pennsylvania Cystic Fibrosis Center and were genotyped for the <jats:italic>TAS2R38<\/jats:italic> locus. To assess sinonasal symptom severity, a 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022) was collected from each patient. Additional demographic and medical history data was obtained at the time of patient enrollment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 49 \u0394F508 homozygous CF patients aged 18 to 32 years were included in the final SNOT\u201022 score analysis. Individuals with 2 functional T2R38 alleles (PAV\/PAV) had significantly lower SNOT\u201022 scores (n = 49, <jats:italic>p<\/jats:italic> &lt; 0.05). On further breakdown of SNOT\u201022 subcategories, rhinologic symptoms specifically were less severe in PAV\/PAV patients than patients with other genotypes (n = 47, <jats:italic>p<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our investigation indicates that T2R38 genotype correlates both with SNOT\u201022 scores and rhinologic\u2010specific QOL in \u0394F508 homozygous CF patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21675","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T16:06:20Z","timestamp":1450368380000},"page":"356-361","source":"Crossref","is-referenced-by-count":55,"title":["T2R38 genotype is correlated with sinonasal quality of life in homozygous \u0394F508 cystic fibrosis patients"],"prefix":"10.1002","volume":"6","author":[{"given":"Nithin D.","family":"Adappa","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Perelman School of Medicine University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan D.","family":"Workman","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Perelman School of Medicine University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Hadjiliadis","sequence":"additional","affiliation":[{"name":"Paul F. Harron Jr. Lung Center, Department of Medicine, Perelman School of Medicine University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Dorgan","sequence":"additional","affiliation":[{"name":"Paul F. Harron Jr. Lung Center, Department of Medicine, Perelman School of Medicine University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Frame","sequence":"additional","affiliation":[{"name":"Paul F. Harron Jr. Lung Center, Department of Medicine, Perelman School of Medicine University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Perelman School of Medicine University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel","family":"Doghramji","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Perelman School of Medicine University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James N.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Perelman School of Medicine University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrine","family":"Mansfield","sequence":"additional","affiliation":[{"name":"Monell Smell and Taste Center  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle R.","family":"Reed","sequence":"additional","affiliation":[{"name":"Monell Smell and Taste Center  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam A.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Perelman School of Medicine University of Pennsylvania  Philadelphia PA"},{"name":"Monell Smell and Taste Center  Philadelphia PA"},{"name":"Philadelphia Veterans Affairs Medical Center  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043184"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:21:1:51"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-1993(09)60005-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2500\/105065897781446810"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90183-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.5.9712056"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.4193\/Rhino10.225","article-title":"Nasal polyposis and cystic fibrosis (CF): review of the literature","volume":"49","author":"Feuillet\u2010Fieux MN","year":"2011","journal-title":"Rhinology"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-1993(13)00150-1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2011.09.009"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814541627a307"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21412"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92449-C"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000029497"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.16.8789"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911934107"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64240"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21140"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21253"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-012-0334-8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.104711"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2008.05.011"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2000.00114.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90353-R"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.6.080604.162340"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1045"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2008.04.003"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2344"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1080190"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.066688"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21675","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:10:54Z","timestamp":1696605054000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,17]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1002\/alr.21675"],"URL":"https:\/\/doi.org\/10.1002\/alr.21675","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,17]]}}}