{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T03:55:54Z","timestamp":1777262154616,"version":"3.51.4"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T00:00:00Z","timestamp":1452470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Aspirin\u2010exacerbated respiratory disease (AERD) is a clinical triad consisting of aspirin\/acetylsalicylic acid (ASA) sensitivity, bronchial asthma, and nasal polyposis. Although respiratory reactions following ingestion of ASA and other nonsteroidal anti\u2010inflammatory drugs (NSAIDs) are considered a hallmark of the condition, respiratory inflammation persists despite patients\u2019 avoidance of NSAIDs. Treatment of this condition remains challenging and includes both medical and surgical options.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective crossover single\u2010blind multicenter study involving 4 tertiary rhinology care centers (n = 30) was conducted in which patients were randomized to start with either 6 weeks of a regular diet or 6 weeks of a low\u2010salicylate diet and then crossed\u2010over for a total study duration of 12 weeks. Patients were evaluated at baseline, 6 weeks (at crossover) and 12 weeks using subjective measures (22\u2010item Sino\u2010Nasal Outcome Test\u201022 [SNOT\u201022], Nasal Sinus Symptom Scale [NSSS], and 7\u2010item Asthma Control Questionnaire [ACQ\u20107]) and objective outcome instruments (Perioperative Sinus Evaluation [POSE] and Lund\u2010Kennedy Endoscopic Score [LKES]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data was analyzed for 30 patients. Wilcoxon rank sum tests determined that patients had improvement in their median difference in scores, which were all statistically significant, when they followed the low\u2010salicylate diet compared to their regular diet: SNOT\u201022: 15 (95% confidence interval [CI], 10 to 23.25),\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001; NSSS: 3 (95% CI, 1.75 to 4),\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001; ACQ\u20107: 4.5 (95% CI, 1.5 to 8.5),\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001; POSE 6 (95% CI, 2.5 to 10),\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001; and LKES: 2.5 (95% CI, 1.5 to 4),\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The low\u2010salicylate diet may offer a novel treatment adjunct to the current management of AERD. Clinically and statistically significant improvements on both subjective and objective outcome measures were noted for the upper and lower respiratory tracts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.21678","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T02:23:31Z","timestamp":1452479011000},"page":"385-391","source":"Crossref","is-referenced-by-count":53,"title":["A novel treatment adjunct for aspirin exacerbated respiratory disease: the low\u2010salicylate diet: a multicenter randomized control crossover trial"],"prefix":"10.1002","volume":"6","author":[{"given":"Doron D.","family":"Sommer","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery Department of Surgery McMaster University  Hamilton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian W.","family":"Rotenberg","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head 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