{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:36:35Z","timestamp":1791999395312,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T00:00:00Z","timestamp":1450310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Olfactory loss is a cardinal symptom of chronic rhinosinusitis (CRS) and affects 40% to 80% of patients. However, common sinus\u2010specific quality\u2010of\u2010life (QOL) instruments include only single questions related to olfaction. Few studies have explored olfactory outcomes after surgery utilizing validated, olfaction\u2010specific QOL questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with CRS were enrolled from 3 centers across North America into a prospective cohort study. Patients completed the short modified version of the Questionnaire of Olfactory Disorders (QOD\u2010NS) and the 40\u2010item Smell Identification Test (SIT\u201040) before and at least 6 months after endoscopic sinus surgery (ESS). Multivariate linear regression was used to determine whether specific demographic, comorbidity, or disease severity measures were independently associated with QOD scores at baseline or predicted change after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 121 patients, equally split between genders, were enrolled with an average age of 47.9 years (range, 18\u201380 years). Baseline total QOD\u2010NS scores were significantly associated with SIT\u201040 scores, with a moderate strength of correlation (<jats:italic>R<\/jats:italic>s = 0.400; <jats:italic>p<\/jats:italic> &lt; 0.001). The average QOD\u2010NS score improved after ESS (35.7 \u00b1 13.0 vs 39.7 \u00b1 12.2; <jats:italic>p<\/jats:italic> = 0.006). Allergy, polyps, and steroid\u2010dependent conditions were found to be independently associated with worse preoperative QOD\u2010NS scores, whereas septal deviation was associated with better QOD\u2010NS scores. Baseline computed tomography (CT) scores were the only variable that significantly predicted change in QOD\u2010NS after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Olfaction\u2010specific QOL is worse in patients with polyps and comorbid allergy. Significant improvements in olfaction\u2010specific QOL are seen after ESS, with the greatest gains seen in those with worse CT scores at baseline.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21679","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T16:06:18Z","timestamp":1450368378000},"page":"407-413","source":"Crossref","is-referenced-by-count":62,"title":["Olfactory\u2010specific quality of life outcomes after endoscopic sinus surgery"],"prefix":"10.1002","volume":"6","author":[{"given":"Zachary M.","family":"Soler","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health Sciences University  Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremiah A.","family":"Alt","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Utah  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay R.","family":"Ramakrishnan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Colorado  Denver CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess C.","family":"Mace","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health Sciences University  Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney J.","family":"Schlosser","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32834dfb3d"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21410"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318170b5cb"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(97)70126-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21408"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23349"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.06.085"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318184e216"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20045"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3286"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino10.049"},{"key":"e_1_2_6_13_1","first-page":"172","article-title":"Evaluation of prognostic factors for olfaction in nasal polyposis treated by endoscopic sinus surgery","volume":"47","author":"Danielides V","year":"2009","journal-title":"Rhinology"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24113"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3476"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.12.006"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3477"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3262"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21679","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:11:01Z","timestamp":1696605061000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,17]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1002\/alr.21679"],"URL":"https:\/\/doi.org\/10.1002\/alr.21679","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,17]]}}}