{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:20:14Z","timestamp":1790194814364,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T00:00:00Z","timestamp":1450310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2016,5]]},"abstract":"\n Background<\/jats:title>\n Diagnostic nasal endoscopy is a routine measure of sinonasal inflammation in patients with chronic rhinosinusitis (CRS). Although multiple staging systems have been proposed and evaluated, evidence of association between concurrent symptoms and endoscopic findings remains discordant. The goal of this study is to identify the relevant endoscopic attributes associated with symptom burden, and to systematically derive a weighted endoscopic scale that optimizes prediction of concurrent symptoms.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Reported baseline symptom (22\u2010item Sino\u2010Nasal Outcome Test [SNOT\u201022]) and endoscopic evaluation scores (Lund\u2010Kennedy [LK]) were obtained from patients with CRS enrolled in a prospective cohort study. Canonical correlation analysis of the SNOT\u201022 subdomains and LK variables was completed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 629 patients were included in analysis including 343 with prior endoscopic sinus surgery. Significant canonical correlations outperformed aggregate correlations in explaining variance of the data (33% vs 3%, respectively). The first canonical correlation was dominated by the rhinologic symptom domain and the endoscopic polyp score (\n r<\/jats:italic>\n = 0.54;\n p<\/jats:italic>\n < 0.05) whereas additional significant canonical correlation was found between the extra\u2010rhinologic symptom subdomain and the edema score in patients without prior ESS (\n r<\/jats:italic>\n = 0.21;\n p<\/jats:italic>\n < 0.05), and discharge in patients with prior ESS (\n r<\/jats:italic>\n = 0.22;\n p<\/jats:italic>\n < 0.05). All other domains and endoscopic variables did not significantly contribute to the canonical correlation.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Although aggregate symptoms and endoscopic scores demonstrate minimal correlation, a weighted combination of symptom domains and endoscopic attributes greatly improves this correlation. A simple approximation of the weights of each of the endoscopic variables of polyps, edema, discharge, scarring, and crusting, is an approximate ratio of 4:2:1:0:0, respectively.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alr.21683","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T11:06:07Z","timestamp":1450350367000},"page":"478-485","source":"Crossref","is-referenced-by-count":32,"title":["Development of a clinically relevant endoscopic grading system for chronic rhinosinusitis using canonical correlation analysis"],"prefix":"10.1002","volume":"6","author":[{"given":"Adam S.","family":"DeConde","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery University of California San Diego, San Diego CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd E.","family":"Bodner","sequence":"additional","affiliation":[{"name":"Department of Psychology Portland State University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess C.","family":"Mace","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health and Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremiah A.","family":"Alt","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology University of Utah School of Medicine Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Rudmik","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health and Science University Portland 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