{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T08:26:28Z","timestamp":1721118388329},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T00:00:00Z","timestamp":1452470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH (National Heart, Lung, and Blood Institute [NHLBI]","award":["5T35HL007744-20"],"award-info":[{"award-number":["5T35HL007744-20"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Nasal closure has been shown to effectively manage severe epistaxis refractory to other treatments in patients with hereditary hemorrhagic telangiectasia (HHT). The nasal closure procedure may be underutilized because of its surgical complexity and flap breakdown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This work is a retrospective review of 13 HHT patients treated for severe epistaxis with nasal closure between 2005 and 2013. Operating room (OR) time, need for revision surgery, preprocedure, and postprocedure epistaxis severity score (ESS), complete blood count values, and Glasgow Benefit Inventory (GBI) questionnaire results were collected for each patient. The technique is described. We characterize a typical nasal closure patient and compare outcomes based on our experience with the traditional 3\u2010flap closure and a simplified 2\u2010flap nasal closure procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average candidate for nasal closure in this series had an ESS of 7.88, hemoglobin (Hgb) of 8.3 g\/dL, and received multiple transfusions, iron therapy, and cautery\/coagulation procedures. Average ESS subsequent to nasal closure using the 2\u2010flap method is 0.92 and mean GBI score is 56.3. Comparison of 5 patients who underwent the traditional 3\u2010flap nasal closure procedure and 8 patients receiving the 2\u2010flap nasal closure showed no significant difference in postoperative ESS or GBI metrics. Mean operating room times of the traditional and simplified methods were 3.12 hours and 1.44 hours (<jats:italic>p<\/jats:italic> = 0.0001). Mean time to first revision for 8 nasal closure patients was 21.5 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In short\u2010term follow\u2010up, the 2\u2010flap procedure showed comparable effectiveness with significantly reduced complexity and operative time compared to the traditional nasal closure method.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21703","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T07:22:08Z","timestamp":1452496928000},"page":"544-548","source":"Crossref","is-referenced-by-count":5,"title":["Treatment of severe refractory epistaxis in hereditary hemorrhagic telangiectasia using a two\u2010flap nasal closure method"],"prefix":"10.1002","volume":"6","author":[{"given":"Benjamin H.","family":"Timmins","sequence":"first","affiliation":[{"name":"School of Medicine University of Utah  Salt Lake City UT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin N.","family":"Hunter","sequence":"additional","affiliation":[{"name":"School of Medicine University of Utah  Salt Lake City UT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin F.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery University of Utah  Salt Lake City UT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. Daniel","family":"Ward","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery University of Utah  Salt Lake City UT"},{"name":"Facial Plastic and Reconstructive Surgery University of Utah  Salt Lake City UT"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,11]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"544","article-title":"Genotype\u2010phenotype correlations in hereditary hemorrhagic telangiectasia: Data from the French\u2010Italian HHT network","volume":"6","author":"Lesca G","year":"2007","journal-title":"Genet Med"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.GIM.0000132689.25644.7C"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1677-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-004-0911-0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3145"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000154754.39797.43"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.01.005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21415"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22501"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100117517"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199409000-00023"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100136369"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2012.26.3809"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100128026"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2011.03.003"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100067426"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20818"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949610500601"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21099"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21703","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21703","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T00:01:53Z","timestamp":1696636913000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,11]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1002\/alr.21703"],"URL":"https:\/\/doi.org\/10.1002\/alr.21703","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,11]]}}}