{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:07:48Z","timestamp":1777424868092,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T00:00:00Z","timestamp":1455580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Staphylococcus pseudintermedius<\/jats:italic> is a gram\u2010positive bacterium commonly found as part of the normal skin and nasal flora of healthy dogs. It may act as an opportunistic pathogen in dogs, but has also been shown to colonize the nasal mucosa of humans. We report 4 cases of chronic rhinosinusitis (CRS) refractory to aggressive medical management with cultures that grew <jats:italic>S. pseudintermedius<\/jats:italic>, with clinical improvement only after initiating culture\u2010directed therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of 4 patients with CRS treated at a tertiary academic medical center with sinonasal cultures growing <jats:italic>S. pseudintermedius<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 4 patients are dog owners and had clinical diagnoses of CRS. Three of the 4 patients had a diagnosis related to immune dysfunction (sarcoidosis, Crohn's disease, history of lymphoma). After undergoing endoscopic sinus surgery, each patient was treated with aggressive medical therapy but continued to have purulent nasal discharge. Sinonasal cultures repeatedly grew <jats:italic>S. pseudintermedius<\/jats:italic> in all cases, with 3 patients\u2019 dogs also having had concurrent <jats:italic>S. pseudintermedius<\/jats:italic> wound infections of the ear and leg with similar antibiotic susceptibilities. Treatment with culture\u2010directed therapy improved the infections in all cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Opportunistic pathogens have a propensity to exacerbate infection in CRS patients with immune dysfunction. We report the first case series of sinonasal <jats:italic>S. pseudintermedius<\/jats:italic> infection in humans. Though a rare cause of disease, pathogens such as <jats:italic>S. pseudintermedius<\/jats:italic> from nonhuman hosts should be considered in the management of CRS patients refractory to medical therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21732","type":"journal-article","created":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T09:11:14Z","timestamp":1455613874000},"page":"710-715","source":"Crossref","is-referenced-by-count":26,"title":["Canine <i>Staphylococcus pseudintermedius<\/i> sinonasal infection in human hosts"],"prefix":"10.1002","volume":"6","author":[{"given":"Edward C.","family":"Kuan","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery, University of California Los Angeles (UCLA)  Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander J.","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, University of California Los Angeles (UCLA)  Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Vijayan","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of California Los Angeles (UCLA)  Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romney M.","family":"Humphries","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of California Los Angeles (UCLA)  Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey D.","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, University of California Los Angeles (UCLA)  Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.63413-0"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr367"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2007.11.016"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3181b0baa9"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq241"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.syapm.2010.11.004"},{"key":"e_1_2_5_8_1","first-page":"M100","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing; Twenty\u2010Fifth Informational Supplement. 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