{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T14:03:15Z","timestamp":1770472995759,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T00:00:00Z","timestamp":1457913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with aspirin\u2010exacerbated respiratory disease (AERD) and chronic rhinosinusitis with nasal polyps (CRSwNP) are often reported to be recalcitrant to standard medical and surgical intervention. Failure rates of standard endoscopic sinus surgery in these patients are reported to be as high as 90%. We review the outcomes for our cohort of AERD patients undergoing endoscopic sinus surgery and endoscopic modified Lothrop procedure (EMLP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data was collected prospectively between January 2001 and December 2013. Information including demographics, asthma status, aspirin sensitivity, 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022), Lund\u2010Mackay scores, and endoscopic ostium assessment were collected for up to 5 years. Minimum follow\u2010up was 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 31 AERD patients underwent complete sphenoethmoidectomy, maxillary antrostomy and EMLP during the study period with an average follow\u2010up of 36 months. Polyp recurrence was seen in a total of 18 patients (58%). Seven patients required revision EMLP following initial surgery demonstrating a failure rate of 22.5%. AERD patients had a statistically significant increased risk of both nasal polyps recurrence and need for revision surgery. Revision EMLP was needed due to recurrence of nasal polyps in 6 cases and frontal ostium stenosis in a single case. Time to revision EMLP was similar between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Complete sphenoethmoidectomy, maxillary antrostomy, and EMLP is successful in a significant majority of patients with AERD and CRSwNP. It is well tolerated with a low complication rate and facilitates successful ongoing medical management of the condition in patients with AERD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21739","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T00:49:38Z","timestamp":1458348578000},"page":"820-825","source":"Crossref","is-referenced-by-count":76,"title":["Outcomes of modified endoscopic Lothrop in aspirin\u2010exacerbated respiratory disease with nasal polyposis"],"prefix":"10.1002","volume":"6","author":[{"given":"David K.","family":"Morrissey","sequence":"first","affiliation":[{"name":"School of Medicine The University of Queensland  Brisbane Australia"},{"name":"Department of Otolaryngology, The Queen Elizabeth Hospital  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Bassiouni","sequence":"additional","affiliation":[{"name":"Department of Surgery\u2013Otorhinolaryngology Head 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