{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T19:07:11Z","timestamp":1782414431164,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T00:00:00Z","timestamp":1457913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with recurrent sinonasal polyposis after endoscopic sinus surgery (ESS) have limited treatment options. Safety and efficacy were previously reported for a bioabsorbable sinus implant that elutes mometasone furoate for 3 months. Here we summarize longer\u2010term outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized, controlled, blinded study with 100 chronic rhinosinusitis with nasal polyps (CRSwNP) patients who failed medical treatment and were considered candidates for revision ESS. Treated patients (n = 57) underwent in\u2010office implant placement. Control patients (n = 43) underwent a sham procedure. Endoscopic grading at 3 months by clinicians was corroborated by an independent review of randomized videoendoscopies by a panel of 3 sinus surgeons. Six\u2010month follow\u2010up included endoscopic grading and patient\u2010reported outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 6 months, treated patients experienced significant improvement in Nasal Obstruction Symptom Evaluation (NOSE) score (<jats:italic>p<\/jats:italic> = 0.021) and &gt;2\u2010fold improvement in mean nasal obstruction\/congestion score (\u22121.06 \u00b1 1.4 vs \u22120.44 \u00b1 1.4; <jats:italic>p<\/jats:italic> = 0.124). Endoscopically, treated patients experienced significant reduction in ethmoid sinus obstruction (<jats:italic>p<\/jats:italic> &lt; 0.001) and bilateral polyp grade (<jats:italic>p<\/jats:italic> = 0.018) compared to controls. Panel review confirmed a significant reduction in ethmoid sinus obstruction (<jats:italic>p<\/jats:italic> = 0.010) and 2\u2010fold improvement in bilateral polyp grade (<jats:italic>p<\/jats:italic> = 0.099), which reached statistical significance (<jats:italic>p<\/jats:italic> = 0.049) in a subset of 67 patients with baseline polyp burden \u22652 bilaterally. At 6 months, control patients were at 3.6 times higher risk of remaining indicated for ESS than treated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The symptomatic and endoscopic improvements observed confirm the efficacy of the steroid\u2010eluting implant for in\u2010office treatment of CRSwNP after ESS. These longer\u2010term 6\u2010month study results demonstrate that the steroid\u2010eluting implant represents a durable, safe, and effective treatment strategy for this patient population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21741","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T00:49:36Z","timestamp":1458348576000},"page":"573-581","source":"Crossref","is-referenced-by-count":64,"title":["RESOLVE: bioabsorbable steroid\u2010eluting sinus implants for in\u2010office treatment of recurrent sinonasal polyposis after sinus surgery: 6\u2010month outcomes from a randomized, controlled, blinded study"],"prefix":"10.1002","volume":"6","author":[{"given":"Keith D.","family":"Forwith","sequence":"first","affiliation":[{"name":"Advanced ENT and Allergy  Louisville KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph K.","family":"Han","sequence":"additional","affiliation":[{"name":"Divisions of Rhinology and Endoscopic Sinus\u2010Skull Base Surgery and Allergy Eastern Virginia Medical School  Norfolk VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Pablo","family":"Stolovitzky","sequence":"additional","affiliation":[{"name":"ENT of Georgia  Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Yen","sequence":"additional","affiliation":[{"name":"Bethlehem Ear, Nose and Throat Associates  Bethlehem PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh K.","family":"Chandra","sequence":"additional","affiliation":[{"name":"Rhinology, Sinus and Skull Base Surgery, Department of Otolaryngology Vanderbilt University  Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Karanfilov","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Ohio State University Ohio Sinus Institute  Dublin OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith E.","family":"Matheny","sequence":"additional","affiliation":[{"name":"Collin County Ear Nose and Throat  Frisco TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Stambaugh","sequence":"additional","affiliation":[{"name":"Clinical Affairs, Intersect ENT  Menlo Park CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna K.","family":"Gawlicka","sequence":"additional","affiliation":[{"name":"Clinical Affairs, Intersect ENT  Menlo Park CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2500\/ar.2013.4.0045"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3950"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0392"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3982"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24027"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.07.027"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.2.179"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200023010-00002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22228"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811435968"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20020"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21416"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21309"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21414"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21426"},{"key":"e_1_2_7_17_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol Suppl"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.09.005"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.09.016"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.2"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21741","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T20:49:12Z","timestamp":1696538952000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,14]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1002\/alr.21741"],"URL":"https:\/\/doi.org\/10.1002\/alr.21741","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,14]]}}}