{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:54:05Z","timestamp":1789977245292,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T00:00:00Z","timestamp":1458172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Interleukin (IL)\u20109 and IL\u201017C have been known to play a role in allergic inflammation, yet, their roles in chronic rhinosinusitis (CRS) are not well defined. IL\u20109 induces changes in epithelial cell gene expression leading to goblet cell metaplasia, whereas IL\u201017C is functionally distinct in that its expression can be induced by bacterial challenge and inflammatory stimuli. This study aimed to compare levels of IL\u20109 and IL\u201017C in CRS with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP) as well as atopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nasal polyp or sinus mucosal specimens from CRSwNP (n = 36), CRSsNP (n = 9), and control (n = 9) groups were collected and processed. Patient atopy status was determined by history of skin\u2010prick test and pulmonary function test. Immunohistochemistry was carried out using anti\u2010human IL\u20109 and IL\u201017C antibodies. Positively\u2010stained cells were enumerated under high\u2010power (\u00d7400) magnification in 5 consecutive fields.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The level of expression of IL\u20109 was higher in CRSwNP than CRSsNP and control. Similar findings were demonstrated in IL\u201017C with higher expression in CRSwNP than CRSsNP and control. Both the averages of positively\u2010stained cells expressing IL\u20109 and IL\u201017C were higher in CRS with asthma and allergy compared to control. This suggested that IL\u20109 and IL\u201017C were both involved in the pathogenesis of CRS, allergy, and asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Inflammatory cell expression of IL\u20109 and IL\u201017C were increased in CRS, particularly with allergy and asthma. These interleukins may contribute to the pathogenesis of CRSwNP as well as atopy and may serve as therapeutic targets for disease management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21745","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T02:15:43Z","timestamp":1458353743000},"page":"841-847","source":"Crossref","is-referenced-by-count":22,"title":["Interleukin\u20109 and interleukin\u201017C in chronic rhinosinusitis"],"prefix":"10.1002","volume":"6","author":[{"given":"Clara M.","family":"Olcott","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Eastern Virginia Medical School  Norfolk VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph K.","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Eastern Virginia Medical School  Norfolk VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina D.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health Eastern Virginia Medical School  Norfolk VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine B.","family":"Franzese","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Eastern Virginia Medical School  Norfolk VA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000200504.54425.0e"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.7.1307"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.12.009"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.71.1.1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2683-x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815572097"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2500\/ar.2014.5.0078"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003049"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxt039"},{"key":"e_1_2_7_11_1","first-page":"19","article-title":"Up\u2010regulation of interleukin\u20109 and the interleukin\u20109\u2010associated calcium\u2010activated chloride channel hCLCA1 in nasal mucosa following in vivo allergen challenge","volume":"3","author":"Hauber HP","year":"2007","journal-title":"Allergy Asthma Clin Immunol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4136"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-010-0098-y"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02422.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2013.5.4.197"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-11-14"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060513478089"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.05.014"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.06.005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02010.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000356"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21745","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T19:58:44Z","timestamp":1696622324000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,17]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1002\/alr.21745"],"URL":"https:\/\/doi.org\/10.1002\/alr.21745","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,17]]}}}