{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T05:25:24Z","timestamp":1768713924047,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T00:00:00Z","timestamp":1458172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>It has been found that the most common adverse reaction which occurs more frequently on cetirizine than on placebo is somnolence. However, the somnolence rate varied widely among different studies. The objective of this study was to assess the somnolence effect of cetirizine 10 mg daily compared to placebo in patients aged 6 years and older using meta\u2010analysis and explore the sources of heterogeneity among different studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Databases were searched for randomized controlled trials (RCTs) of cetirizine published before 2015. Overall risk differences (RDs) were determined by meta\u2010analyses of 13 trials using the DerSimonian and Laird (D&amp;L) method based on fixed\u2010effects and random\u2010effect models, respectively. The Q statistic, H statistic, and I<jats:sup>2<\/jats:sup>were calculated for heterogeneity analysis. Subgroup analysis, Galbraith plot, sensitivity analysis, and meta\u2010regression were also performed to explore the sources of heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Various analyses showed that heterogeneity existed among the 13 trials and the placebo run\u2010in period was the cause of heterogeneity. For RCTs without and with placebo run\u2010in period, the overall RDs were 6.51% (95% CI, 4.47% to 8.56%) and 1.03% (95% CI, \u22120.13% to 2.19%), respectively, which indicated that the difference in somnolence rate between cetirizine 10 mg daily and placebo was not statistically significant for the subgroup with placebo run\u2010in.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The meta\u2010analysis showed that the RDs between cetirizine 10 mg daily and placebo on somnolence rate were different for studies with and without a placebo run\u2010in period. The results for studies with a placebo run\u2010in period suggested that cetirizine 10 mg daily has no somnolence effect compared to placebo.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21746","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T02:15:41Z","timestamp":1458353741000},"page":"871-879","source":"Crossref","is-referenced-by-count":4,"title":["Placebo\u2010controlled assessment of somnolence effect of cetirizine: a meta\u2010analysis"],"prefix":"10.1002","volume":"6","author":[{"given":"Qiong","family":"Du","sequence":"first","affiliation":[{"name":"Department of Statistics and Actuarial Sciences East China Normal University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingchun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Statistics and Actuarial Sciences East China Normal University Shanghai 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