{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:25:09Z","timestamp":1789475109197,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,3,25]],"date-time":"2016-03-25T00:00:00Z","timestamp":1458864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Allergic rhinitis (AR) is a multifactorial immunologic disease that is influenced by both genetic and environment factors. House dust mites (HDMs) are important inhalant aeroallergens and are an epidemiologic risk factor for AR. Similarly, the human leukocyte antigen (HLA) class II genes DQB1 and DRB1 have been shown to be associated with AR and play an important role in the regulation of the immune response. The objective of this work was to elucidate the HLA\u2010II gene alleles associated with AR in HDM\u2010sensitive Han Chinese subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 142 patients with AR and 184 healthy subjects were recruited to this case\u2010control study. Diagnosis of AR was based on medical history, laryngological examination, skin\u2010prick tests, and HMD\u2010specific immunoglobulin E (IgE) assays. Genotyping of HLA\u2010DRB1 and HAL\u2010DQB1 was performed by the polymerase chain reaction sequence\u2010based genotyping method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 35 alleles of the HLA\u2010DRB1 locus and 19 alleles of the HLA\u2010DQB1 locus were genotyped in the entire study cohort; the frequencies of alleles DQB1*06:01:01 (corrected <jats:italic>p<\/jats:italic> value [<jats:italic>p<\/jats:italic><jats:sub>c<\/jats:sub>] = 0.009; odds ratio [OR] = 2.684; 95% confidence interval [CI] = 1.482 to 4.994) and DRB1*08:03:02 (<jats:italic>p<\/jats:italic><jats:sub>c<\/jats:sub> = 0.009; OR = 3.754; 95% CI = 1.724 to 8.851) were significantly increased in HDM\u2010sensitive AR patients compared to healthy controls and are considered to be a risk factor for AR in Chinese Han subjects. The frequency of haplotype DRB1*08:03\u2013DQB1*06:01 in the HDM\u2010sensitive AR group was also significantly higher than in the control group (9.5% vs 2.4%; <jats:italic>p<\/jats:italic><jats:sub>c<\/jats:sub> = 0.005; OR = 4.182; 95% CI = 1.870 to 10.285). Serological antigen types assessment further demonstrated the frequency of HLA\u2010DRB1*08 (<jats:italic>p<\/jats:italic><jats:sub>c<\/jats:sub> = 0.022; OR = 2.982; 95% CI = 1.46 to 6.400) to be significantly increased in HDM\u2010sensitive AR patients, and the frequencies of DRB1*14 (<jats:italic>p<\/jats:italic><jats:sub>c<\/jats:sub> = 0.030; OR = 0.340; 95% CI = 0.154 to 0.694) and DQB1*05 (<jats:italic>p<\/jats:italic><jats:sub>c<\/jats:sub> = 0.030; OR = 0.459; 95% CI = 0.269 to 0.764) to be significantly decreased, compared to healthy controls, suggesting that HLA\u2010DRB1*08 might be a risk factor, and DRB1*14 and DQB1*05 protective factors for HDM\u2010sensitive AR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HLA\u2010DRB1*08:03:02 and HLA\u2010DQB1*06:01:01 are associated with HMD\u2010sensitive AR and may confer a risk for development of AR in Han Chinese subjects sensitized to HDM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21747","type":"journal-article","created":{"date-parts":[[2016,3,25]],"date-time":"2016-03-25T08:08:39Z","timestamp":1458893319000},"page":"854-861","source":"Crossref","is-referenced-by-count":12,"title":["HLA\u2010DRB1*08:03:02 and HLA\u2010DQB1*06:01:01 are associated with house dust mite\u2013sensitive allergic rhinitis in Chinese subjects"],"prefix":"10.1002","volume":"6","author":[{"given":"Yanming","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyun","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"},{"name":"Department of Allergy, Beijing TongRen Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"},{"name":"Department of Allergy, Beijing TongRen Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2011.01029.x"},{"key":"e_1_2_6_3_1","first-page":"23","article-title":"Epidemiology of rhinitis: allergic and nonallergic","volume":"19","author":"Settipane RA","year":"2007","journal-title":"Clin Allergy Immunol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.10.021"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-218-6_35"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2004.00327.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(00)90079-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(99)00112-3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70384-2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00610.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61987-4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2014.6.2.105"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03953.x"},{"key":"e_1_2_6_14_1","first-page":"215","article-title":"Association of HLA class II alleles with childhood asthma and Total IgE levels","volume":"7","author":"Movahedi M","year":"2008","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes5010084"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01377.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00752.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61992-8"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.08.012"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1993.tb04698.x"},{"key":"e_1_2_6_22_1","unstructured":"SinnwellJP SchaidDJ.Haplo Stats (version 1.6.0): Statistical Analysis of Haplotypes When Linkage Phase is Ambiguous.http:\/\/www.mayo.edu\/research\/documents\/manualhaplostats\/doc\u201020167217. Accessed February 27 2016."},{"key":"e_1_2_6_23_1","first-page":"1023","article-title":"Epi Info\u2014present and future","volume":"2003","author":"Su Y","year":"2003","journal-title":"AMIA Annu Symp Proc"},{"key":"e_1_2_6_24_1","unstructured":"R Development Core Team R Foundation for Statistical Computing.R: A Language and Environment for Statistical Computing.http:\/\/www.R\u2010project.org. Accessed February 27 2016."},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0167"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031018"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10147"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2001.00950.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-13-43"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7961-8-5"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2012.4.3.143"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1105-1153"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364284"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2694"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019719"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1996.tb00500.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1994.tb00931.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1996.tb00102.x"},{"key":"e_1_2_6_39_1","first-page":"103","article-title":"[HLA\u2010A, B, DRB1 gene polymorphism of Beijing population was studied by high\u2010resolution polymerase chain reaction sequence\u2010based typing]","volume":"23","author":"Deng YJ","year":"2006","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2011.01029.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2010.10.017"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2011.03.010"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1998.00246.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1998.00224.x"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(03)00109-5"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg059"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12327"},{"key":"e_1_2_6_48_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1398-9995.2007.01620.x","article-title":"Allergic Rhinitis and its Impact on Asthma (ARIA 2008)","volume":"63","author":"Bachert C","year":"2008","journal-title":"Allergy"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/5.12.1589"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(94)90383-2"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21747","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T19:59:15Z","timestamp":1696622355000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,25]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1002\/alr.21747"],"URL":"https:\/\/doi.org\/10.1002\/alr.21747","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,25]]}}}