{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:44:57Z","timestamp":1790282697564,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,4,5]],"date-time":"2016-04-05T00:00:00Z","timestamp":1459814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Program for Changjiang Scholars and Innovative Research Team","award":["IRT13082"],"award-info":[{"award-number":["IRT13082"]}]},{"name":"National Science Fund for the Major International Joint Research Program","award":["81420108009"],"award-info":[{"award-number":["81420108009"]}]},{"name":"12th Five-Year Science and Technology","award":["2014BAI07B04"],"award-info":[{"award-number":["2014BAI07B04"]}]},{"name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development","award":["ZYLX201310"],"award-info":[{"award-number":["ZYLX201310"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81400444, 81470678"],"award-info":[{"award-number":["81400444, 81470678"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Beijing Health Bureau Program for High Level Talents","award":["2011-3-043"],"award-info":[{"award-number":["2011-3-043"]}]},{"name":"Beijing Municipal Administration of Hospitals\u2019 Mission Plan","award":["SML20150203"],"award-info":[{"award-number":["SML20150203"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP), characterized by eosinophil\u2010predominant inflammation in mucosa, is a subject of much investigation. However, no satisfactory atraumatic clinical parameter has been established to date for prediagnosis of this condition. The aim of this study was therefore to compare the use of computed tomography (CT) scans with other clinical parameters in prediagnosis of eCRSwNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective cohort, single\u2010institution study. Two hundred consecutive CRSwNP patients (123 eCRSwNP and 77 non\u2010eosinophilic CRSwNP [neCRSwNP]) undergoing functional endoscopic sinus surgery in Beijing TongRen Hospital were recruited. Preoperative CT scan, skin\u2010prick test (SPT), and oral fractional exhaled nitric oxide (FENO) measurements were performed in each patient and full blood count with differential analysis under the patients\u2019 regular condition was performed within 1 week before surgery. Logistic regression analysis and receiver operating characteristic (ROC) curve were used to assess the predictive value of clinical parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>History of surgery, onset of asthma, history of allergy, total Lund\u2010Mackay scores, presence of osteoneogenesis, FENO, and blood eosinophil counts were all significantly higher in the eCRSwNP group, compared to the neCRSwNP group. The ratio of the CT scores for the ethmoid sinus and maxillary sinus (E\/M ratio) had the highest predictive value, with an area under the ROC curve (AUC) of 0.938. The cutoff point of &gt;2.59 for E\/M ratio demonstrated a sensitivity of 94.2% and a specificity of 89.6% for eCRSwNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The E\/M ratio is a more useful predictor in diagnosis of eCRSwNP compared to the other clinical parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.21749","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T09:04:59Z","timestamp":1460279099000},"page":"812-819","source":"Crossref","is-referenced-by-count":85,"title":["Predictive significance of computed tomography in eosinophilic chronic rhinosinusitis with nasal polyps"],"prefix":"10.1002","volume":"6","author":[{"given":"Yifan","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Beijing TongRen Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfei","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Beijing TongRen Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengshuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Beijing TongRen Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Beijing TongRen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"},{"name":"Department of Allergy, Beijing TongRen Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.10-RAI-0231"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2011.01.007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v2.i12.873"},{"key":"e_1_2_7_5_1","first-page":"195","volume-title":"Oto\u2010Rhino\u2010Laryngology","author":"Haruna S","year":"2001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2005.09.005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240201600606"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.07.036"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000147917.43615.c0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24154"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22507"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.10-OA-0234"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-2910-0"},{"issue":"23","key":"e_1_2_7_14_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2012","volume":"3","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol Suppl"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770005-6"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.017"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s00134-003-1761-8","article-title":"A readers\u2019 guide to the interpretation of diagnostic test properties: clinical example of sepsis","volume":"29","author":"Fisher JE","year":"2003","journal-title":"Intensive Care Med"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.02.036"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12577"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00014404"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240602000118"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3519-7"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.01.079"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.10.018"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240201600301"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.06.085"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000108134"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2014.28.4024"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941011900705"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000126066"},{"key":"e_1_2_7_31_1","first-page":"39","article-title":"Categorization and clinicopathological features of chronic rhinosinusitis with eosinophilic mucin in a Korean population","volume":"1","author":"Suk HL","year":"2015","journal-title":"Clin Exp Otorhinolaryngol"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-2910-0"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01044.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2013.02.001"},{"key":"e_1_2_7_35_1","first-page":"23","article-title":"Nasal fractional exhaled nitric oxide analysis with a novel hand\u2010held device","volume":"46","author":"Weschta M","year":"2008","journal-title":"Rhinology"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21749","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21749","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:58:49Z","timestamp":1696607929000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,5]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1002\/alr.21749"],"URL":"https:\/\/doi.org\/10.1002\/alr.21749","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,5]]}}}