{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:08:06Z","timestamp":1787069286439,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T00:00:00Z","timestamp":1460678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Mayo Clinic Center for Clinical and Translational Science","award":["UL1 TR000135"],"award-info":[{"award-number":["UL1 TR000135"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Women electing endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) report higher symptom burden but have lower computed tomography (CT) scores. Gender\u2010specific analysis of outcomes from ESS therefore merits further study. The objective of this work was to study gender\u2010specific differences in outcomes from ESS for CRS by analyzing preoperative and postoperative 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022) scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from adult CRS patients electing ESS (2011\u20102013) were retrospectively collected. SNOT\u201022 total, rhinologic\/nonrhinologic subdomain, and individual item scores were analyzed for gender\u2010specific differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two hundred and forty\u2010eight patients met study criteria (mean age 55.4 years; 49.6% female). Preoperatively, mean Lund\u2010Mackay CT score was 11.1; average total SNOT\u201022 score was 41.9. Compared to men, women had lower CT score (10.2 vs 12.0;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004) but higher total SNOT\u201022 score (44.7 vs 39.1;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.02). Both genders showed significant improvement in total SNOT\u201022 scores at 3, 6, 12, and 24 months following ESS (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), with largely similar slopes of improvement. The greatest improvement occurred at 3 months (SNOT\u201022 decreased by 25.4 points), with stable improvement after 12 months (SNOT\u201022 decreased by 21.3 points). Higher total SNOT\u201022 scores in females were noted preoperatively and until 6 months post\u2010ESS; these were driven by rhinologic and nonrhinologic\u2010otolaryngic subdomain items. No gender differences in anxiety\/depression prevalence or psychological subdomain scores were noted preoperatively or postoperatively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both male and female CRS patients showed significant and durable symptom relief following ESS. Women reported higher symptom burden prior to surgery, and in the early postoperative period. However, after 1\u2010year post\u2010ESS, both genders showed similar symptom scores. The trend and magnitude of improvement were similar in both genders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.21773","type":"journal-article","created":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T07:29:50Z","timestamp":1460705390000},"page":"896-905","source":"Crossref","is-referenced-by-count":38,"title":["Gender\u2010specific analysis of outcomes from endoscopic sinus surgery for chronic rhinosinusitis"],"prefix":"10.1002","volume":"6","author":[{"given":"Devyani","family":"Lal","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mayo Clinic in Arizona  Phoenix AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly B.","family":"Golisch","sequence":"additional","affiliation":[{"name":"School of Medicine University of Arizona  Tucson AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary A.","family":"Elwell","sequence":"additional","affiliation":[{"name":"School of Molecular Sciences Arizona State University  Tempe AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit D.","family":"Divekar","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma, and Clinical Immunology Mayo Clinic in Rochester  Rochester MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Rank","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma, and Clinical Immunology Mayo Clinic in Arizona  Phoenix AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hui","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Mayo Clinic in Arizona  Phoenix AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,15]]},"reference":[{"issue":"23","key":"e_1_2_7_2_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol Suppl"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000182825.82910.80"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21667"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2230-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25411"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770005-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.10.009"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000224575.12945.90"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700105"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200412-1738OC"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2010.07.014"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21458"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21773","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T14:39:09Z","timestamp":1696603149000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,15]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1002\/alr.21773"],"URL":"https:\/\/doi.org\/10.1002\/alr.21773","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,15]]}}}