{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T10:27:07Z","timestamp":1773829627402,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The present study investigated the effectiveness of a <jats:italic>Pimpinella anisum<\/jats:italic>\u2013based herbal medicine for treating chronic rhinosinusitis (CRS) without polyps in comparison to fluticasone nasal spray, in a single\u2010blinded randomized trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with CRS without nasal polyps were randomly assigned into 2 treatment groups: individuals in the first group (n = 26) received 2 drops of a <jats:italic>P. anisum<\/jats:italic>\u2013based herbal medicine (Sinupim) in each nostril every 12 hours, while those in the second group (n = 22) received 2 puffs of fluticasone nasal spray in each nostril every 12 hours. Both groups used their designated treatments for 4 weeks. Patients were evaluated by the 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022) at the start of the trial and after the completion of their treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although both treatments were effective in reducing patients\u2019 symptoms, there were significantly better results in the Sinupim group based on the SNOT\u201022 evaluation. Mean changes in computed tomography (CT) scan scoring in Sinupim and fluticasone groups before and after treatment were 2.22 \u00b1 2.94 and 0.76 \u00b1 1.39, respectively, which was significant within both groups (<jats:italic>p<\/jats:italic> &lt; 0.05). Postnasal drip and nasal obstruction were more significantly improved in the Sinupim group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A <jats:italic>P. anisum<\/jats:italic>\u2013based herbal medicine may be an effective treatment for sinusitis without polyps. However, its wide acceptance needs further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21785","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T02:31:39Z","timestamp":1464143499000},"page":"943-949","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of a novel natural drop for treatment of chronic rhinosinusitis without nasal polyps: a single blind randomized trial"],"prefix":"10.1002","volume":"6","author":[{"given":"Shima","family":"Vazifehkah","sequence":"first","affiliation":[{"name":"Department of Iranian Traditional Medicine, School of Iranian Traditional Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Reza","family":"Shams\u2010Ardekani","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Kamalinejad","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Mousa","family":"Saderhossein","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamed","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Clinical Trial Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Mohammad","family":"Shams","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, South Tehran Branch Islamic Azad University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirin","family":"Abbassi","sequence":"additional","affiliation":[{"name":"Department of Iranian Traditional Medicine, School of Iranian Traditional Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sareh","family":"Eghtesad","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babak","family":"Saedi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/hn.2003.v128.amhn0312811"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.109269"},{"key":"e_1_2_6_4_1","first-page":"1","article-title":"Summary health statistics for U.S. adults: National Health Interview Survey, 2008","volume":"242","author":"Pleis JR","year":"2009","journal-title":"Vital Health Stat 10"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino12.000"},{"key":"e_1_2_6_6_1","first-page":"75","article-title":"Topical corticosteroids in chronic rhinosinusitis: a randomized, double\u2010blind, placebo\u2010controlled trial using fluticasone propionate aqueous nasal spray","volume":"39","author":"Parikh A","year":"2001","journal-title":"Rhinology"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3282fdcc9a"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.06.1254"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.5.1461"},{"key":"e_1_2_6_10_1","first-page":"346","article-title":"Complementary therapeutic practices in patients with chronic sinusitis","volume":"3","author":"Krouse HJ","year":"1999","journal-title":"Clin Excell Nurse Pract"},{"key":"e_1_2_6_11_1","unstructured":"DuggalNM ParikhSR WyattND. 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