{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:17:38Z","timestamp":1773674258914,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T00:00:00Z","timestamp":1466035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002583","name":"Gyeongsang National University","doi-asserted-by":"publisher","award":["IHS GNU\u20102013\u201002"],"award-info":[{"award-number":["IHS GNU\u20102013\u201002"]}],"id":[{"id":"10.13039\/501100002583","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI13C13590000"],"award-info":[{"award-number":["HI13C13590000"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Although topical corticosteroids are considered a safe and effective drug for allergic rhinitis (AR), some AR patients do not show sufficient symptomatic improvement by use of topical corticosteroids. Topical cyclosporine is a safe and effective drug for patients with allergic conjunctivitis, particularly for those with steroid\u2010resistant allergic conjunctivitis. We investigated the anti\u2010inflammatory effects of intranasal cyclosporine for AR using a mouse model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After establishment of allergic inflammation in 5\u2010week\u2010old BALB\/c mice, cyclosporine was administered intranasally 3 times per week for 2 weeks. To confirm its anti\u2010inflammatory effects, triamcinolone acetonide (TAC) was utilized as a control drug. Histopathologic changes were evaluated using Sirius red and Giemsa staining for eosinophilic and mast cell infiltration, respectively. The levels of cytokines in sinonasal tissues, including tumor necrosis factor (TNF), interleukin (IL)\u20104, IL\u20105, and IL\u201013, were assessed based on a cytometric bead array.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The degree of eosinophilic infiltration was significantly decreased by instillation of cyclosporine, the potency being similar to TAC. However, the number of mast cells was not decreased by cyclosporine or TAC. The levels of TNF, IL\u20104, IL\u20105, and IL\u201013 were significantly decreased after treatment with cyclosporine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The anti\u2010inflammatory effects of topical cyclosporine for AR were equivalent to those of topical corticosteroids. Topical cyclosporine may be useful for the treatment of AR, although human studies are required.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21808","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T17:39:51Z","timestamp":1466098791000},"page":"1139-1144","source":"Crossref","is-referenced-by-count":7,"title":["Anti\u2010inflammatory effects of intranasal cyclosporine for allergic rhinitis in a mouse model"],"prefix":"10.1002","volume":"6","author":[{"given":"Yeon\u2010Hee","family":"Joo","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Gyeongsang National University Hospital  Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Yeop","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Gyeongsang National University Hospital  Jinju Republic of Korea"},{"name":"Institute of Health Sciences Gyeongsang National University  Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences Gyeongsang National University  Jinju Republic of Korea"},{"name":"Biomedical Research Institute Gyeongsang National University Hospital  Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myeong Hee","family":"Jung","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute Gyeongsang National University Hospital  Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jino","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST)  Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun\u2010Jin","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Gyeongsang National University Hospital  Jinju Republic of Korea"},{"name":"Institute of Health Sciences Gyeongsang National University  Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sea\u2010Yuong","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Gyeongsang National University Hospital  Jinju Republic of Korea"},{"name":"Institute of Health Sciences Gyeongsang National University  Jinju Republic of Korea"},{"name":"Department of Otorhinolaryngology Gyeongsang National University School of Medicine  Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong\u2010Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences Gyeongsang National University  Jinju Republic of Korea"},{"name":"Department of Ophthalmology Gyeongsang National University Hospital  Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang\u2010Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Gyeongsang National University Hospital  Jinju Republic of Korea"},{"name":"Institute of Health Sciences Gyeongsang National University  Jinju Republic of Korea"},{"name":"Department of Otorhinolaryngology Gyeongsang National University School of Medicine  Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70053-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-3109(00)00192-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2013.838557"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e328364d86a"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.02.063"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.05.013"},{"key":"e_1_2_6_9_1","first-page":"631","article-title":"Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease","volume":"107","author":"Sall K","year":"2000","journal-title":"CsA Phase 3 Study Group. 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