{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T03:18:49Z","timestamp":1781839129719,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T00:00:00Z","timestamp":1466035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DC005805"],"award-info":[{"award-number":["R01 DC005805"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Health utility scores quantify an individual's valuation of particular health states and are vital components of health economic studies and cost\u2010effectiveness research. We sought to characterize health utility values for patients with recurrent acute rhinosinusitis (RARS) both before and after endoscopic sinus surgery (ESS), as well as compare health utility to chronic rhinosinusitis without nasal polyposis (CRSsNP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with RARS (n = 20) and CRSsNP (n = 20) undergoing ESS were enrolled as part of a longitudinal, observational, prospective cohort. Case patients diagnosed with RARS were age\u2010 and gender\u2010matched to controls with CRSsNP using a nested case\u2010control design at a 1:1 ratio. Health utility was measured using the Medical Outcomes Study Short Form\u20106D (SF\u20106D) survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with RARS were followed for an average of 14.0 \u00b1 6.1 (mean \u00b1 standard deviation) months compared to an average of 14.4 \u00b1 5.3 months for CRSsNP controls (<jats:italic>p<\/jats:italic> = 0.779). Mean preoperative SF\u20106D health utility scores were statistically comparable between RARS (0.71 \u00b1 0.14) and CRSsNP (0.66 \u00b1 0.12; <jats:italic>p<\/jats:italic> = 0.341). Both patients with RARS and CRSsNP reported significant postoperative improvement in SF\u20106D scores from 0.71 \u00b1 0.14 to 0.79 \u00b1 0.13 (<jats:italic>p<\/jats:italic> = 0.031) and from 0.66 \u00b1 0.12 to 0.77 \u00b1 0.13 (<jats:italic>p<\/jats:italic> = 0.004), respectively. No difference in last postoperative SF\u20106D scores were found between RARS and CRSsNP (<jats:italic>p<\/jats:italic> = 0.583) or in the average magnitude of postoperative improvement (0.08 \u00b1 0.16 vs 0.11 \u00b1 0.13; <jats:italic>p<\/jats:italic> = 0.620).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with RARS and CRSsNP report significant impairment in health utility as measured by the SF\u20106D. ESS significantly improves health utility in patients with RARS and CRSsNP to near normative values. These data will help inform future economic analysis and cost\u2010effectiveness research.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21809","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T17:39:55Z","timestamp":1466098795000},"page":"1182-1187","source":"Crossref","is-referenced-by-count":14,"title":["Health utility values for patients with recurrent acute rhinosinusitis undergoing endoscopic sinus surgery: a nested case control study"],"prefix":"10.1002","volume":"6","author":[{"given":"Toby O.","family":"Steele","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of California Davis Medical Center  Sacramento CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess C.","family":"Mace","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus Surgery, Oregon Sinus Center, Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health and Science University  Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Dedhia","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of California Davis Medical Center  Sacramento CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Rudmik","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus Surgery, Oregon Sinus Center, Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health and Science University  Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremiah A.","family":"Alt","sequence":"additional","affiliation":[{"name":"Sinus and Skull Base Surgery Program, Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery University of Utah  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815572097"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25705"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3177"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811426089"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1011024"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23943"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21847"},{"key":"e_1_2_6_9_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2012","volume":"23","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol Suppl"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21599"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25108"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21364"},{"key":"e_1_2_6_13_1","unstructured":"International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. 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