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The present study investigated the association between asthma and the risk of CRS in a large national sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients newly diagnosed with asthma (International Classification of Diseases, Ninth Revision [ICD\u20109], Clinical Modification code 493) between 2000 and 2008 were identified from the Taiwan National Health Insurance Research Database. The cases were compared with sex\u2010, age\u2010, residence\u2010, and insurance premium\u2013matched controls, and both groups were followed until the end of 2009 for incidences of CRS with or without nasal polyps (CRSwNP or CRSsNP, respectively). Competing risk\u2010adjusted Cox regression analyses were performed after adjustment for sex, age, residence, insurance premium, steroid use, hyperlipidemia, diabetes, hypertension, coronary artery disease, Charlson comorbidity index score, and mortality. We also performed a case\u2010control study to determine the association between asthma and CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort study analysis examined 81,462 patients with a mean \u00b1 standard deviation (SD) follow\u2010up period of 5.8 \u00b1 2.4 years. Asthma was an independent predictor of CRSsNP (hazard ratio = 2.58; 95% confidence interval [CI], 2.20 to 3.03; <jats:italic>p<\/jats:italic> &lt; 0.001) in the fully adjusted models. In the case\u2010control analysis, both CRSwNP and CRSsNP were associated with asthma in the fully adjusted models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Asthma was associated with increased risks of CRSwNP and CRSsNP, independent of several potential confounding factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21813","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T19:29:54Z","timestamp":1467228594000},"page":"1284-1293","source":"Crossref","is-referenced-by-count":20,"title":["Asthma associated with chronic rhinosinusitis: a population\u2010based study"],"prefix":"10.1002","volume":"6","author":[{"given":"Yu\u2010Ting","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Public Health Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen\u2010Yu","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology School of Medicine College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Otorhinolaryngology Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"Department of Otorhinolaryngology Kaohsiung Municipal Hsiao\u2010Kang Hospital  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010Yu","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Family Medicine School of Medicine College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Family Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"Department of Family Medicine Kaohsiung Municipal Ta\u2010Tung Hospital  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiu\u2010Mieh","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Nursing National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles Tzu\u2010Chi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and Health Education National Taiwan Normal University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02244.x"},{"key":"e_1_2_6_3_1","unstructured":"World Health Organization (WHO).Asthma. 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