{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:10:11Z","timestamp":1770999011700,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T00:00:00Z","timestamp":1467849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Current guidelines have identified 10 to 12 weeks posttreatment as the ideal time\u2010point for improved diagnostic accuracy of positron emission tomography\/computed tomography (PET\/CT) for deep tissue sites of the head and neck. After treatment, the sinonasal skull base is predisposed to prolonged inflammation that may render this time\u2010point inappropriate for initial posttreatment imaging surveillance for sinonasal malignancies. The purpose of this study is to evaluate temporal trends in <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose (<jats:sup>18<\/jats:sup>FDG) sinonasal uptake after treatment for sinonasal malignancies to better elucidate the optimal time\u2010point for initial PET\/CT posttreatment evaluation in this patient population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of all successfully treated and non\u2013locally recurrent sinonasal malignancies over a 15\u2010year study period (2000 to 2015) was performed at our institution. Posttreatment <jats:sup>18<\/jats:sup>FDG PET\/CT standardized uptake value data were collected and compared between various time\u2010points (2 to 4 months, 5 to 12 months, 5 to 24 months, and 13 to 24 months) using an independent\u2010samples <jats:italic>t<\/jats:italic> test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A statistically significant difference was noted between the posttreatment time windows 2 to 4 and 5 to 12 months (<jats:italic>p<\/jats:italic> = 0.048) as well as 2 to 4 and 5 to 24 months (<jats:italic>p<\/jats:italic> = 0.02). A trend toward significance was seen when comparing 2 to 4 and 13 to 24 months (<jats:italic>p<\/jats:italic> = 0.083).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our analysis of PET\/CT in patients previously treated for sinonasal malignancy suggests that the posttreatment sinonasal skull base is characterized by a prolonged period of hypermetabolism that endures beyond the period previously described for deep tissue sites of the head and neck. These findings prompt a reevaluation of the previously described 10\u2010 to 12\u2010week cutoff point for initial posttreatment PET\/CT for head and neck squamous cell carcinoma as applied to sinonasal malignancies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21814","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T10:37:41Z","timestamp":1467887861000},"page":"1301-1307","source":"Crossref","is-referenced-by-count":20,"title":["Temporal patterns of <sup>18<\/sup>F\u2010fluorodeoxyglucose positron emission tomography\/computed tomography sinonasal uptake after treatment of sinonasal malignancy"],"prefix":"10.1002","volume":"6","author":[{"given":"Joseph S.","family":"Schwartz","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania  Perelman School of Medicine Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven G.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania  Perelman School of Medicine Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Stubbs","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania  Perelman School of Medicine Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankona","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania  Perelman School of Medicine Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bobby A.","family":"Tajudeen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania  Perelman School of Medicine Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sammy","family":"Khalili","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania  Perelman School of Medicine Philadelphia PA"},{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Aurora Medical Group, Milwaukee  WI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James N.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania  Perelman School of Medicine Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Y.K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Pennsylvania Perelman School of Medicine  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Ali","family":"Nabavizadeh","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pennsylvania  Perelman School of Medicine Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim O.","family":"Learned","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pennsylvania  Perelman School of Medicine Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nithin D.","family":"Adappa","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania  Perelman School of Medicine Philadelphia 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