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Several medical interventions have been investigated, but a formal comprehensive evaluation of the evidence has never been performed. The purpose of this article is to provide an evidence\u2010based approach for the multidisciplinary management of CRS in AERD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review of the literature was performed and the guidelines for development of an evidence\u2010based review with recommendations were followed. Study inclusion criteria included: adult population &gt;18 years old; CRS based on published diagnostic criteria, and a presumptive diagnosis of AERD. We focused on reporting higher\u2010quality studies (level 2 or higher) when available, but reported lower\u2010quality studies if the topic contained insufficient evidence. Treatment recommendations were based on American Academy of Otolaryngology (AAO) guidelines, with defined grades of evidence and evaluation of research quality and risk\/benefits associated with each treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This review identified and evaluated the literature on 3 treatment strategies for CRS in AERD: dietary salicylate avoidance, leukotriene modification, and desensitization with daily aspirin therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on the available evidence, dietary salicylate avoidance and leukotriene\u2010modifying drugs are options following appropriate treatment with nasal corticosteroids and saline irrigation. Desensitization with daily aspirin therapy is recommended following revision endoscopic sinus surgery (ESS).<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21826","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T13:27:54Z","timestamp":1470230874000},"page":"1273-1283","source":"Crossref","is-referenced-by-count":54,"title":["Contemporary management of chronic rhinosinusitis with nasal polyposis in aspirin\u2010exacerbated respiratory disease: an evidence\u2010based review with recommendations"],"prefix":"10.1002","volume":"6","author":[{"given":"Joshua M.","family":"Levy","sequence":"first","affiliation":[{"name":"Division of Rhinology and Sinus\/Skull Base Surgery, Oregon Sinus Center, Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health and Science University  Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Rudmik","sequence":"additional","affiliation":[{"name":"Division of 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