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Nitrogen dioxide (NO<jats:sub>2<\/jats:sub>) is a pervasive air pollutant that is associated with respiratory diseases. Given the olfactory nerve's anatomic exposure to airborne pollutants, we investigated the relationship between NO<jats:sub>2<\/jats:sub> exposure and olfactory dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The ability to identify odors was evaluated using a validated test in respondents from the National Social Life, Health, and Aging Project (NSHAP), a representative probability sample of home\u2010dwelling, older U.S. adults age 57 to 85 years. Exposure to NO<jats:sub>2<\/jats:sub> pollution was assessed using measurements obtained from the U.S. Environmental Protection Agency (EPA) Aerometric Information Retrieval System (AIRS) ambient monitoring site closest to each respondent's home. We tested the association between NO<jats:sub>2<\/jats:sub> exposure and olfactory dysfunction using multivariate logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among older adults in the United States, 22.6% had impaired olfactory function, defined as \u22643 correct (out of 5) on the odor identification test. Median NO<jats:sub>2<\/jats:sub> exposure during the 365 days prior to the interview date was 14.7 ppb (interquartile range [IQR], 10.8 to 19.7 ppb). An IQR increase in NO<jats:sub>2<\/jats:sub> exposure was associated with increased odds of olfactory dysfunction (OR, 1.35; 95% CI, 1.07 to 1.72), adjusting for age, gender, race\/ethnicity, education, cognition, comorbidity, smoking, and season of the home interview (n = 1823).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We show for the first time that NO<jats:sub>2<\/jats:sub> exposure is associated with olfactory dysfunction in older U.S. adults. These results suggest an important role for NO<jats:sub>2<\/jats:sub> exposure on olfactory dysfunction, and, potentially, nasal disease more broadly.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21829","type":"journal-article","created":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T10:42:49Z","timestamp":1473763369000},"page":"1245-1252","source":"Crossref","is-referenced-by-count":36,"title":["Nitrogen dioxide pollution exposure is associated with olfactory dysfunction in older U.S. adults"],"prefix":"10.1002","volume":"6","author":[{"given":"Dara R.","family":"Adams","sequence":"first","affiliation":[{"name":"Pritzker School of Medicine The University of Chicago  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav S.","family":"Ajmani","sequence":"additional","affiliation":[{"name":"Pritzker School of Medicine The University of Chicago  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian C.","family":"Pun","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Bouve College of Health Sciences Northeastern University  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen E.","family":"Wroblewski","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences The University of Chicago  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Kern","sequence":"additional","affiliation":[{"name":"Department of Psychology Northeastern Illinois University  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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