{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T19:26:00Z","timestamp":1780860360194,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T00:00:00Z","timestamp":1473379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2010\/17580\u20101"],"award-info":[{"award-number":["2010\/17580\u20101"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/04148\u20102"],"award-info":[{"award-number":["2013\/04148\u20102"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The management of acute exacerbation of chronic rhinosinusitis (AECRS) is still under debate, especially because there are no adequate studies to support a best\u2010evidence treatment for this condition. Antibiotic use for AECRS has been recommended based on extrapolation of data from acute rhinosinusitis (ARS) or non\u2013placebo\u2010controlled studies. This study aimed to evaluate whether antibiotic therapy modifies the course of AECRS in a randomized, placebo\u2010controlled study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with AECRS were randomized in a double\u2010blinded manner (2:1 ratio) to receive either amoxicillin\u2010clavulanate 875 mg\/125 mg twice daily (BID) (AMX\u2010CLAV, n = 21) or placebo capsules (n = 11) during 14 days. All patients were also treated with mometasone furoate and nasal washes with saline. Global sinonasal symptoms (Severity Symptom Assessment [SSA]), quality of life (22\u2010item Sino\u2010Nasal Outcome Test [SNOT\u201022]), nasal endoscopic score (Lund\u2010Kennedy), and microbiological evaluation were compared to evaluate the efficacy of antibiotic therapy in AECRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Despite the majority of bacteria cultured from the middle meatus swab were sensitive for AMX\u2010CLAV (84%), both AMX\u2010CLAV and placebo\u2010treated groups presented the same clinical course, with no difference between groups. Both groups exhibited overall improvement of symptoms on day 14 compared to day 0 (<jats:italic>p<\/jats:italic> &lt; 0.01), especially the items \u201cnasal secretion\u201d and \u201cnasal obstruction\u201d (<jats:italic>p<\/jats:italic> &lt; 0.05). We also observed the same evolution of nasal endoscopic and quality of life scores between placebo and AMX\u2010CLAV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We concluded that AMX\u2010CLAV for 14 days did not change the clinical course of AECRS compared with placebo. The addition of an oral antibiotic to ongoing topical intranasal steroid spray may not provide additional benefit during management of AECRS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21846","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T21:00:38Z","timestamp":1473454838000},"page":"135-142","source":"Crossref","is-referenced-by-count":34,"title":["Amoxicillin\u2010clavulanate for patients with acute exacerbation of chronic rhinosinusitis: a prospective, double\u2010blinded, placebo\u2010controlled trial"],"prefix":"10.1002","volume":"7","author":[{"given":"Henrique Augusto Cantareira","family":"Sabino","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery Division of Otorhinolaryngology Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo (USP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana Cardoso Pereira","family":"Valera","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery Division of Otorhinolaryngology Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo (USP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davi Casale","family":"Aragon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ribeir\u00e3o Preto Medical School University of Sao Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Zilio","family":"Fantucci","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery Division of Otorhinolaryngology Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo (USP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Carneiro","family":"Titoneli","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery Division of Otorhinolaryngology Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo (USP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo (USP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma T.","family":"Anselmo\u2010Lima","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery Division of Otorhinolaryngology Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo (USP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Tamashiro","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery Division of Otorhinolaryngology Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo (USP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-015-0540-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2002.14.5.508"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000239310"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21695_c"},{"key":"e_1_2_7_7_1","first-page":"Cd011994","article-title":"Systemic and topical antibiotics for chronic rhinosinusitis","volume":"4","author":"Head K","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000191560.53555.08"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfami.2.5.497"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200405000-00027"},{"issue":"20","key":"e_1_2_7_11_1","first-page":"1","article-title":"Mullol J; European Position Paper on Rhinosinusitis and Nasal Polyps group. 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