{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T13:24:59Z","timestamp":1773062699565,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T00:00:00Z","timestamp":1478476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004357","name":"Procter and Gamble","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Viral rhinitis (the \u201ccommon\u201d cold) is a frequent worldwide disease. Olfactory dysfunction is one complication that arises during infection, which in most cases heals up spontaneously upon recovery, whereas in some cases it may persist as a partial or total loss of olfaction. The aim of this prospective study was to investigate the change of other chemosensory systems during a cold.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010eight patients (age 18 to 69 years) with an acute cold were compared to a healthy control group (n = 59; age 19 to 63 years). All patients were examined on 2 occasions separated by approximately 4 weeks. Orthonasal, retronasal, gustatory, and trigeminal nasal function were investigated. Furthermore, ratings of real foods, in terms of intensity and pleasantness, were obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the control group, patients showed a decreased orthonasal (threshold and discrimination) and retronasal function. Furthermore, patients exhibited a decreased sensitivity to salt and a reduced ability to localize menthol, indicating a decreased taste and trigeminal function, respectively. Upon recovery from the infection, orthonasal olfactory and trigeminal sensitivity increased, whereas retronasal sensitivity showed no improvement and salt sensitivity decreased.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This comprehensive study provides empirical evidence that chemosensory impairment is prevalent during a cold, and additionally shows for the first time that chemosensory features associated with food consumption persist postinfection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21869","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T16:55:40Z","timestamp":1478537740000},"page":"185-191","source":"Crossref","is-referenced-by-count":40,"title":["Investigation of chemosensitivity during and after an acute cold"],"prefix":"10.1002","volume":"7","author":[{"given":"Robert","family":"Pellegrino","sequence":"first","affiliation":[{"name":"Smell &amp; Taste Clinic, Department of Otorhinolaryngology \u201cTechnische Universit\u00e4t Dresden,\u201d  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ute","family":"Walliczek\u2010Dworschak","sequence":"additional","affiliation":[{"name":"Smell &amp; Taste Clinic, Department of Otorhinolaryngology \u201cTechnische Universit\u00e4t Dresden,\u201d  Dresden Germany"},{"name":"Department of Otorhinolaryngology Philipps\u2010University  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gudrun","family":"Winter","sequence":"additional","affiliation":[{"name":"Smell &amp; Taste Clinic, Department of Otorhinolaryngology \u201cTechnische Universit\u00e4t Dresden,\u201d  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Hull","sequence":"additional","affiliation":[{"name":"Procter and Gamble  Surrey UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hummel","sequence":"additional","affiliation":[{"name":"Smell &amp; Taste Clinic, Department of Otorhinolaryngology \u201cTechnische Universit\u00e4t Dresden,\u201d  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,7]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Division of Viral Diseases. 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