{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:48:01Z","timestamp":1792180081876,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T00:00:00Z","timestamp":1479859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003354","name":"Garnett Passe and Rodney Williams Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003354","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003449","name":"Green Lane Research and Educational Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2017,3]]},"abstract":"\n Background<\/jats:title>\n Despite considerable research, the pathogenesis of chronic rhinosinusitis (CRS) remains poorly understood. Potential microbial roles in the etiology or progression of CRS have long been hypothesized, yet few specific associations have been identified. In this study we investigate associations between patterns in resident bacterial communities and clinical variants of CRS.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Bacterial communities were assessed in 94 patients with extensive bilateral CRS undergoing endoscopic sinus surgery (ESS) and 29 controls undergoing ESS for indications other than CRS. Patients were grouped on the basis of phenotypic variants (with or without polyposis) and clinical parameters, including asthma and cystic fibrosis. Bacterial communities were characterized via 16S rRNA gene amplicon sequencing, and quantified by quantitative polymerase chain reaction.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Controls and idiopathic CRS subjects tended to be dominated by members of the genera\n Corynebacterium<\/jats:italic>\n and\n Staphylococcus<\/jats:italic>\n , together with lower abundances of several other genera, including\n Streptococcus<\/jats:italic>\n ,\n Moraxella<\/jats:italic>\n , and\n Haemophilus<\/jats:italic>\n . Aberrant (dysbiotic) bacterial assemblages (with changes in community membership and structure, reduced diversity, and increased bacterial load) and increased inter\u2010 and intrasubject variability were more common in subjects with comorbidities such as asthma and cystic fibrosis. Dysbiotic communities were variably dominated by members of the genera\n Staphylococcus<\/jats:italic>\n ,\n Streptococcus<\/jats:italic>\n ,\n Haemophilus<\/jats:italic>\n ,\n Pseudomonas<\/jats:italic>\n ,\n Moraxella<\/jats:italic>\n , or\n Fusobacterium<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Bacterial community dysbiosis was more apparent than specific associations with examined phenotypes or endotypes, and may play a role in the pathogenesis or influence the severity of CRS. Reductions in several common core bacterial taxa, increased inter\u2010 and intrasubject variability, reduced bacterial diversity, and increased bacterial load characterized aberrant bacterial communities in CRS.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alr.21871","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T07:58:17Z","timestamp":1479887897000},"page":"230-239","source":"Crossref","is-referenced-by-count":164,"title":["Evidence of microbiota dysbiosis in chronic rhinosinusitis"],"prefix":"10.1002","volume":"7","author":[{"given":"Michael","family":"Hoggard","sequence":"first","affiliation":[{"name":"School of Biological Sciences University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi","family":"Biswas","sequence":"additional","affiliation":[{"name":"School of Medicine University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Zoing","sequence":"additional","affiliation":[{"name":"School of Medicine University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Wagner Mackenzie","sequence":"additional","affiliation":[{"name":"School of Medicine University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Taylor","sequence":"additional","affiliation":[{"name":"School of Biological Sciences University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"Douglas","sequence":"additional","affiliation":[{"name":"School of Medicine University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,23]]},"reference":[{"issue":"23","key":"e_1_2_7_2_1","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2012","volume":"50","author":"Fokkens WJ","year":"2012","journal-title":"Rhinology"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70152-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3355"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941112000701"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0463.2000.d01-13.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.1999.0680"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003783"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.11.005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00134"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.02.008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2016.30.4261"},{"key":"e_1_2_7_13_1","article-title":"Changes in the bacterial microbiome of patients with chronic rhinosinusitis after endoscopic sinus surgery","author":"Jain R","journal-title":"Int Forum Allergy Rhinol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240501900116"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21057"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2011.41"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq461"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.f.303"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00062-07"},{"key":"e_1_2_7_20_1","article-title":"R Foundation for Statistical Computing","author":"R Core Team","year":"2015","journal-title":"R: A Language and Environment for Statistical Computing"},{"key":"e_1_2_7_21_1","article-title":"Vegan Community Ecology Package","author":"Oksanen J","year":"2015","journal-title":"R Package Version 2.3.2"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00401706.1964.10490181"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1961.10482090"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-6-r60"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21159"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3366"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22398"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21805"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21630"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-015-0172-9"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12474"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607116658762"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309897"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00248-014-0504-4"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38892"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1114-16.2016"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1586\/17512433.2016.1150780"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.02.002"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21195"}],"container-title":["International Forum of Allergy & Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21871","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T04:24:34Z","timestamp":1696566274000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,23]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1002\/alr.21871"],"URL":"https:\/\/doi.org\/10.1002\/alr.21871","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,23]]}}}