{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:32:16Z","timestamp":1788820336867,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T00:00:00Z","timestamp":1479859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis (CRS) and bacterial sinusitis are ubiquitous in patients with primary ciliary dyskinesia (PCD). From the sinuses, <jats:italic>Pseudomonas aeruginosa<\/jats:italic> can infect the lungs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied the effect of endoscopic sinus surgery (ESS) on symptoms of CRS and lower airway infections in PCD patients in a prospective single\u2010arm intervention study of ESS with adjuvant therapy using nasal irrigation with saline, topical nasal steroids, and 2 weeks of systemic antibiotics. Additional treatment with local colistin for 6 months was instigated when <jats:italic>P. aeruginosa<\/jats:italic> was cultured at ESS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four PCD patients underwent ESS to search for an infectious focus (n = 10), due to severe symptoms of CRS (n = 8), or both (n = 6). Bacteria were cultured from sinus samples in 21 patients (88%), and simultaneous sinus and lung colonization with identical pathogens were observed in 13 patients (62%). Four patients with preoperative <jats:italic>P. aeruginosa<\/jats:italic> lung colonization (25%) had no regrowth during follow\u2010up; 2 of these had <jats:italic>P. aeruginosa<\/jats:italic> sinusitis. Sinonasal symptoms were improved 12 months after ESS and we observed a trend toward better lung function after ESS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We demonstrated an improvement in CRS\u2010related symptoms after ESS and adjuvant therapy. In selected PCD patients, the suggested regimen may postpone chronic lung infection with <jats:italic>P. aeruginosa<\/jats:italic> and stabilize lung function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21873","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T12:57:09Z","timestamp":1479905829000},"page":"240-247","source":"Crossref","is-referenced-by-count":62,"title":["Sinus surgery can improve quality of life, lung infections, and lung function in patients with primary ciliary dyskinesia"],"prefix":"10.1002","volume":"7","author":[{"given":"Mikkel Christian","family":"Alanin","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery and Audiology  Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Aanaes","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery and Audiology  Rigshospitalet 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