{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:46:20Z","timestamp":1787748380090,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,26]],"date-time":"2016-11-26T00:00:00Z","timestamp":1480118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG HU441\/18\u20101"],"award-info":[{"award-number":["DFG HU441\/18\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to investigate the effect of MP\u2010AzeFlu on olfaction and the interaction between severity of allergic rhinitis and olfactory improvement after therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, multicenter, observational study was performed on 47 patients with persistent allergic rhinitis. Duration and severity of allergic rhinitis was diagnosed and classified using the modified Allergic Rhinitis and its Impact on Asthma (ARIA) criteria and the proof of allergen sensitization from positive skin\u2010prick tests, specific immonoglobulin E (IgE) in serum, and nasal provocation response. Patients were treated with MP\u2010AzeFlu (1 spray\/nostril twice daily) over 3 months. Olfactory function was assessed at baseline and at 1 and 3 months of therapy using the \u201cSniffin\u2019 Sticks\u201d test. In addition, a nasal symptom score was recorded on a visual analog scale (VAS) at each given time\u2010point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MP\u2010AzeFlu was found to be associated with a significant improvement in TDI score, from 23.7 at baseline to 34.2 at 1 month (<jats:italic>p<\/jats:italic> &lt; 0.001) and 37.1 at 3 months (<jats:italic>p<\/jats:italic> &lt; 0.001) of treatment. Furthermore, a highly significant improvement of symptoms over time (<jats:italic>p<\/jats:italic> &lt; 0.001; VAS at baseline: 84.3; 1 month: 32.4; 3 months: 26.2) could be demonstrated. Most importantly, there was a highly significant interaction between the severity of allergic rhinitis and olfactory function (<jats:italic>p<\/jats:italic> &lt; 0.001) and VAS (<jats:italic>p<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MP\u2010AzeFlu is associated with olfactory improvement in persistent allergic rhinitis patients. Further, the modified ARIA severity classification is an indicator of patients\u2019 olfactory function. Moreover, assessment of olfaction seems to be a reliable indicator of the clinical success of antiallergic\/antiinflammatory therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21877","type":"journal-article","created":{"date-parts":[[2016,11,26]],"date-time":"2016-11-26T16:26:49Z","timestamp":1480177609000},"page":"287-292","source":"Crossref","is-referenced-by-count":22,"title":["Olfaction in patients with allergic rhinitis: an indicator of successful MP\u2010AzeFlu therapy"],"prefix":"10.1002","volume":"7","author":[{"given":"Ludger","family":"Klimek","sequence":"first","affiliation":[{"name":"Zentrum f\u00fcr Rhinologie und Allergologie  Wiesbaden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia C.","family":"Poletti","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre \u201cSmell &amp; Taste,\u201d Department of Otorhinolaryngology Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Sperl","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Rhinologie und Allergologie  Wiesbaden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Spielhaupter","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Rhinologie und Allergologie  Wiesbaden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornel","family":"Bardenhewer","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Rhinologie und Allergologie  Wiesbaden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim","family":"Mullol","sequence":"additional","affiliation":[{"name":"Rhinology Unit and Smell Clinic Department of Otorhinolaryngology, Hospital Clinic IDIBAPS, Universitat de Barcelona, CIBERES; 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