{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T05:47:20Z","timestamp":1792388840690,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T00:00:00Z","timestamp":1482105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Predicting which patients are at a higher risk for recurrent chronic rhinosinusitis with nasal polyps (CRSwNP) is one of the most challenging problems in clinical rhinology. A direct association between CRSwNP recurrence rates and serum eosinophil and basophil counts was reported. This study aimed to identify best\u2010fitting cutoffs for binarizing preoperative serum eosinophils and basophils (counts\/percentages) for prognostic purposes in cases of CRSwNP recurrence after surgery. A secondary endpoint was to distinguish said cutoffs for prognosticating recurrence in subcohorts of patients with histologically diagnosed eosinophilic\/non\u2010eosinophilic CRSwNP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was performed on 280 patients (127 eosinophilic and 153 non\u2010eosinophilic CRSwNP) examining the prognostic role of serum eosinophil and basophil levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For all patients examined, mean preoperative serum eosinophil and basophil levels were significantly higher in patients whose CRSwNP recurred. Patients with eosinophil counts \u22650.24 cells \u00d7 10<jats:sup>9<\/jats:sup>\/L and percentages \u22653.7% had odds ratios (ORs) of 2.57 and 2.19 for recurrence; patients with basophil counts \u22650.03 cells \u00d7 10<jats:sup>9<\/jats:sup>\/L and percentages \u22650.5% had ORs of 2.19 and 2.24, respectively. Among histologically eosinophilic CRSwNP patients, mean eosinophils and basophils (counts\/percentages) were significantly higher in cases that recurred. Serum eosinophil and basophil values were directly correlated. The recurrence odds were OR 2.52 for high eosinophils (\u22655.9%), and OR 2.52 and 2.69 for high basophils (\u22650.04 cells \u00d7 10<jats:sup>9<\/jats:sup>\/L and \u22650.5%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High serum eosinophil and basophil values should be further investigated because they could pinpoint patients at higher risk of eosinophilic\u2010type CRSwNP recurrence. These preliminary results support the increasing interest in the role of basophils in CRSwNP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21885","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T15:16:45Z","timestamp":1482160605000},"page":"261-267","source":"Crossref","is-referenced-by-count":77,"title":["The prognostic role of serum eosinophil and basophil levels in sinonasal polyposis"],"prefix":"10.1002","volume":"7","author":[{"given":"Giuseppe","family":"Brescia","sequence":"first","affiliation":[{"name":"Department of Neurosciences (DNS) Otolaryngology Section Padova University  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Barion","sequence":"additional","affiliation":[{"name":"Department of Neurosciences (DNS) Otolaryngology Section Padova University  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Zanotti","sequence":"additional","affiliation":[{"name":"Department of Neurosciences (DNS) Otolaryngology Section Padova University  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Giacomelli","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED) Padova University  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Martini","sequence":"additional","affiliation":[{"name":"Department of Neurosciences (DNS) Otolaryngology Section Padova University  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gino","family":"Marioni","sequence":"additional","affiliation":[{"name":"Department of Neurosciences (DNS) Otolaryngology Section Padova University  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-014-0427-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2016.02.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24154"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3456-x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12644"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2015.01.019"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3753-z"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.5606\/kbbihtisas.2015.10734"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00399"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2016.30.4349"},{"key":"e_1_2_6_12_1","first-page":"137","volume-title":"Nasal Polyposis: An Inflammatory Disease and Its Treatment","author":"Mackay IS","year":"1997"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2011.01.007"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22507"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240201600606"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816637856"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-016-0568-y"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-016-0570-4"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2014.28.4024"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2015.1063784"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3519-7"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21885","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T08:25:20Z","timestamp":1696580720000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,19]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1002\/alr.21885"],"URL":"https:\/\/doi.org\/10.1002\/alr.21885","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,19]]}}}