{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T05:21:27Z","timestamp":1788067287372,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T00:00:00Z","timestamp":1481587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"OHNS-DCRI T32 Clinical Research Training Fellowship","award":["T32DC013018-02"],"award-info":[{"award-number":["T32DC013018-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Tumor necrosis factor alpha (TNF\u2010\u03b1) inhibitors have revolutionized treatment of many inflammatory diseases. Sinusitis after initiation of TNF\u2010\u03b1 inhibitors has been observed, but has not been well described in the literature. We aim to characterize the clinical features of sinusitis in patients on anti\u2010TNF\u2010\u03b1 therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective chart review of 28 patients on a TNF\u2010\u03b1 inhibitor diagnosed with sinusitis by otolaryngologists at Duke University. Patient demographics, sinusitis characteristics, and treatment course were studied by chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of sinusitis diagnosed and treated by an otolaryngologist was less than 1%. Of the 28 patients studied, 12 (42.9%) had a history of preexisting sinusitis and 16 (57.1%) had new\u2010onset sinusitis. 71.4% were diagnosed with chronic rhinosinusitis without polyps (CRSsNP), with disease mainly involving the maxillary and ethmoid sinuses. No patients had major extrasinus complications or required hospital admission or intravenous (IV) antibiotics. 35.7% (n = 10), including 44% (7\/16) of new\u2010onset patients required a surgical intervention after initiating anti\u2010TNF therapy. 14.3% (n = 4) of the cohort had improvement in sinonasal symptoms after stopping, changing, or holding doses of the TNF\u2010\u03b1 inhibitor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anti\u2010TNF\u2010\u03b1 therapy can be associated with new\u2010onset sinusitis, mainly CRSsNP. Overall, the percentage of patients on a TNF\u2010\u03b1 inhibitor seeking consultation from an otolaryngologist is low. While some patients with new\u2010onset sinusitis will require surgery, modification of anti\u2010TNF\u2010\u03b1 therapy should be considered as an option in the medical management of these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21895","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T11:36:42Z","timestamp":1481629002000},"page":"380-384","source":"Crossref","is-referenced-by-count":17,"title":["Sinusitis in patients on tumor necrosis factor alpha inhibitors"],"prefix":"10.1002","volume":"7","author":[{"given":"Cynthia S.","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Head and Neck Surgery &amp; Communication Sciences Department of Surgery Duke University Medical Center  Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Honeybrook","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Surgery &amp; Communication Sciences Department of Surgery Duke University Medical Center  Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Chapurin","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Surgery &amp; 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