{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T05:33:16Z","timestamp":1769059996418,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2014M552363"],"award-info":[{"award-number":["2014M552363"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Decreased expression of airway epithelial\u2010specific transcription factor NK2 homeobox 1 (NKX2\u20101) was associated with allergic inflammation in asthma patients. However, the expression and role of NKX2\u20101 in nasal polyps (NPs) with different endotypes were undefined yet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined the expression of key cytokines (interleukin [IL]\u20104 IL\u20105, IL\u201013, and IL\u201017A, etc.) and NKX2\u20101 in NPs with different endotypes and control tissues by immunohistochemistry staining, qualitative polymerase chain reaction (qPCR), enzyme\u2010linked immunosorbent assay (ELISA), and Western blot analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found 23% of chronic rhinosinusitis (CRS) with NP (CRSwNP) patients had IL\u20105<jats:sup>+<\/jats:sup> eosinophilic NPs, 40.7% of NPs were key cytokines negative NPs (KCN NPs) with less eosinophil accumulation. The expression of NKX2\u20101 in IL\u20105<jats:sup>+<\/jats:sup> NPs was significantly lower than KCN NPs and normal controls (<jats:italic>p<\/jats:italic> &lt; 0.05). The expression of mucin 5AC (MUC5AC) and MUC5B, as well as goblet cells hyperplasia, were significantly elevated in IL\u20105<jats:sup>+<\/jats:sup> NPs, which correlated with the decreased expression of NKX2\u20101 (<jats:italic>p<\/jats:italic> &lt; 0.05). Moreover, \u201cSAM pointed domain containing ETS transcription factor\u201d (SPDEF) was significantly elevated, while expression of Forkhead Box A2 (FoxA2) was significantly decreased in IL\u20105<jats:sup>+<\/jats:sup> NPs (<jats:italic>p<\/jats:italic> &lt; 0.05). The expression of chemokine (C\u2010C motif) ligand 17 (CCL17) and IL\u20104 was significantly increased in IL\u20105<jats:sup>+<\/jats:sup> NPs, which was associated with eosinophil accumulation(<jats:italic>p<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The downregulation of NKX2\u20101 in IL\u20105<jats:sup>+<\/jats:sup> NPs may be associated with tissue eosinophilia and goblet cells hyperplasia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21932","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T10:23:34Z","timestamp":1490005414000},"page":"690-698","source":"Crossref","is-referenced-by-count":9,"title":["Distinct expression of NK2 homeobox 1 (NKX2\u20101) and goblet cell hyperplasia in nasal polyps with different endotypes"],"prefix":"10.1002","volume":"7","author":[{"given":"Jintao","family":"Du","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luo","family":"Ba","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology People's Hospital of the Tibet Autonomous Region  Lasha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianting","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Affiliated Eye, Ear, Nose and Throat Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yafeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junming","family":"Xian","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sixi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery West China Hospital Sichuan University  Chengdu 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