{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:26:05Z","timestamp":1789727165424,"version":"4.0.1"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T00:00:00Z","timestamp":1495065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R03 DC013651\u201001 to Z.M.S"],"award-info":[{"award-number":["R03 DC013651\u201001 to Z.M.S"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis (CRS) significantly impacts olfaction. However, the relationship between objective olfaction and patient\u2010reported olfactory\u2010specific quality of life (QOL) is not well understood. Furthermore, objective olfactory testing can be time consuming, so we sought to determine if patient\u2010reported olfactory QOL can be used as screening tool for olfactory dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Olfactory dysfunction was evaluated in 109 patients with CRS using the Questionnaire of Olfactory Disorders\u2013Negative Statements (QOD\u2010NS) and the Sniffin\u2019 Sticks Test, assessing for olfactory threshold, discrimination, identification, and overall composite scores (TDI; composite score of threshold, discrimination, and identification). Regression analysis was performed to correlate olfactory metrics and patient and disease\u2010specific factors with QOD\u2010NS scores. Optimal QOD\u2010NS scores to classify patients based upon objective olfactory function were established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bivariate and multivariate regression analyses of QOD\u2010NS and CRS\u2010associated comorbidities, objective measures of disease, demographics, and CRS\u2010specific QOL were performed. Non\u2010white race, depression, and worse 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022) scores correlated with worse QOD\u2010NS scores (<jats:italic>p<\/jats:italic> &lt; 0.005). Worse TDI scores correlated with worse QOD\u2010NS scores, and discrimination had the strongest correlation (<jats:italic>p<\/jats:italic> &lt; 0.001). Mean \u00b1 standard deviation (SD) QOD\u2010NS scores for normosmia, hyposmia, and anosmia were 44 \u00b1 7.2, 35.7 \u00b1 12.8, and 31.6 \u00b1 10.7, respectively. Receiver operating characteristic curve analysis revealed an area under the curve of 0.770 (<jats:italic>p<\/jats:italic> &lt; 0.001), and a QOD\u2010NS cutoff of 38.5 to have maximal Youden's index to define normal vs abnormal TDI score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In CRS, QOD\u2010NS correlates with non\u2010white race, depression, SNOT\u201022, and TDI score, with discrimination having the strongest correlation. The QOD\u2010NS also appears to be a feasible tool for olfaction screening.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21940","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T17:04:20Z","timestamp":1495127060000},"page":"734-740","source":"Crossref","is-referenced-by-count":57,"title":["Understanding the relationship between olfactory\u2010specific quality of life, objective olfactory loss, and patient factors in chronic rhinosinusitis"],"prefix":"10.1002","volume":"7","author":[{"given":"Jose L.","family":"Mattos","sequence":"first","affiliation":[{"name":"Division of Rhinology and Sinus Surgery Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney J.","family":"Schlosser","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus Surgery Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina  Charleston SC"},{"name":"Department of Surgery Ralph H. Johnson VA Medical Center  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina A.","family":"Storck","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus Surgery Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary M.","family":"Soler","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus Surgery Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,18]]},"reference":[{"issue":"23","key":"e_1_2_6_2_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2012","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol Suppl"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815574247"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21679"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21841"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjw080"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770005-6"},{"key":"e_1_2_6_8_1","first-page":"183","article-title":"Staging in rhinosinusitus","volume":"31","author":"Lund VJ","year":"1993","journal-title":"Rhinology"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23349"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/22.1.39"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0173-0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21496"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26229"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21940","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:21:04Z","timestamp":1696605664000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,18]]},"references-count":13,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1002\/alr.21940"],"URL":"https:\/\/doi.org\/10.1002\/alr.21940","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,18]]}}}